Risau W
Max-Planck-Institut für Psychiatrie, Abteilung Neurochemie, Martinsried, F.R.G.
Prog Growth Factor Res. 1990;2(1):71-9. doi: 10.1016/0955-2235(90)90010-h.
Angiogenesis, the formation of new blood vessels, plays a central role in a variety of physiological and pathological processes such as embryonic development, wound healing and tumor growth. It is a complex, multi-step process that involves the migration and proliferation of capillary endothelial cells. Several factors that stimulate the proliferation of endothelial cells in vitro have been shown to induce angiogenesis in vivo. Among these angiogenic growth factors are wide-spectrum multifunctional mitogens (e.g. the fibroblast growth factors) and the recently identified factors with distinct specificity for vascular endothelial cells (e.g. the platelet-derived endothelial cell growth factor). Another group of factors apparently induce angiogenesis indirectly (e.g. transforming growth factor-beta) by stimulating target cells to release angiogenic factors or by other mechanisms. The differential expression, release and activation of these factors might regulate angiogenesis under various physiological and pathological conditions.
血管生成，即新血管的形成，在多种生理和病理过程中发挥着核心作用，如胚胎发育、伤口愈合和肿瘤生长。它是一个复杂的多步骤过程，涉及毛细血管内皮细胞的迁移和增殖。已表明，几种在体外刺激内皮细胞增殖的因子在体内可诱导血管生成。这些血管生成生长因子包括广谱多功能有丝分裂原（如成纤维细胞生长因子）和最近发现的对血管内皮细胞具有独特特异性的因子（如血小板衍生的内皮细胞生长因子）。另一组因子显然通过刺激靶细胞释放血管生成因子或通过其他机制间接诱导血管生成（如转化生长因子-β）。这些因子的差异表达、释放和激活可能在各种生理和病理条件下调节血管生成。
