雄激素性脱发与无症状年轻成年人的动脉僵硬度增加有关。
Androgenetic alopecia is associated with increased arterial stiffness in asymptomatic young adults.
作者信息
Agac M T, Bektas H, Korkmaz L, Cetin M, Erkan H, Gurbak I, Hatem E, Celik S
机构信息
Department of Cardiology, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Trabzon, Turkey.
出版信息
J Eur Acad Dermatol Venereol. 2015 Jan;29(1):26-30. doi: 10.1111/jdv.12424. Epub 2014 Mar 14.
BACKGROUND
Association of androgenetic alopecia (AGA) with increased incidence of hypertension, a strong risk factor for coronary artery disease, has been suggested. However, there are no data on arterial stiffness measures of asymptomatic young adults with AGA.
OBJECTIVE
In this study, we aimed to investigate the association of the AGA with arterial stiffness assessed by cardio-ankle vascular index (CAVI), in asymptomatic young men.
METHODS
A total of 162 asymptomatic men aged between 18 and 45 years were consecutively enrolled to the study. Subjects were considered to have AGA if they have ≥3 grade vertex alopecia according to Hamilton-Norwood scale. Arterial stiffness was assessed by CAVI and defined as abnormal if CAVI is ≥8.
RESULTS
Frequency of abnormal CAVI was higher in patients with AGA (29.3% vs. 10.0%, P = 0.003). Subjects with AGA had higher mean CAVI than subjects without AGA (7.56 ± 0.93 vs. 7.15 ± 0.79, P = 0.004). Binary logistic regression analysis demonstrated that presence of AGA (OR, 5.6; 95% CI, 1.7-20.0, P = 0.006), age (OR, 1.1; 95% CI, 1.0-1.2, P = 0.03) and diastolic blood pressure (OR, 1.1; 95% CI, 1.0-1.3, P = 0.005) were independently associated with abnormal CAVI.
CONCLUSION
We concluded that, AGA might be an indicator of arterial stiffness in asymptomatic young adults.
背景
有研究表明，雄激素性脱发（AGA）与高血压发病率增加有关，而高血压是冠状动脉疾病的一个重要危险因素。然而，目前尚无关于无症状AGA青年成人动脉僵硬度测量的数据。
目的
在本研究中，我们旨在调查无症状青年男性中AGA与通过心踝血管指数（CAVI）评估的动脉僵硬度之间的关联。
方法
共有162名年龄在18至45岁之间的无症状男性连续纳入本研究。根据汉密尔顿-诺伍德量表，如果受试者头顶脱发≥3级，则被认为患有AGA。通过CAVI评估动脉僵硬度，CAVI≥8则定义为异常。
结果
AGA患者中CAVI异常的频率更高（29.3%对10.0%，P = 0.003）。AGA患者的平均CAVI高于无AGA患者（7.56±0.93对7.15±0.79，P = 0.004）。二元逻辑回归分析表明，AGA的存在（OR，5.6；95%CI，1.7 - 20.0，P = 0.006）、年龄（OR，1.1；95%CI，1.0 - 1.2，P = 0.03）和舒张压（OR，1.1；95%CI，1.0 - 1.3，P = 0.005）与CAVI异常独立相关。
结论
我们得出结论，AGA可能是无症状青年成人动脉僵硬度的一个指标。
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