Ding Hong X, Leverett Carolyn A, Kyne Robert E, Liu Kevin K-C, Sakya Subas M, Flick Andrew C, O'Donnell Christopher J
PharmaPhase Co., Ltd, Beijing 100193, China.
Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States.
Bioorg Med Chem. 2014 Apr 1;22(7):2005-32. doi: 10.1016/j.bmc.2014.02.017. Epub 2014 Feb 25.
New drugs introduced to the market every year represent a privileged structure for a particular biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the synthesis of twenty-six NCEs that were launched or approved worldwide in 2012 and two additional drugs which were launched at the end of 2011.
每年推向市场的新药代表了针对特定生物靶点的一种特殊结构。这些新化学实体（NCEs）为分子识别提供了见解，也可作为设计未来新药的先导物。本综述涵盖了2012年在全球推出或获批的26种新化学实体的合成，以及另外两种在2011年底推出的药物。
