Ding Hong X, Leverett Carolyn A, Kyne Robert E, Liu Kevin K-C, Fink Sarah J, Flick Andrew C, O'Donnell Christopher J
Pharmacodia (Beijing) Co., Ltd, Beijing 100085, China.
Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States.
Bioorg Med Chem. 2015 May 1;23(9):1895-922. doi: 10.1016/j.bmc.2015.02.056. Epub 2015 Mar 6.
New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition and also serve as leads for designing future new drugs. This annual review covers the synthesis of twenty-four NCEs that were approved for the first time in 2013 and two 2012 drugs which were not covered during the previous edition of this review.
每年推向市场的新药代表着针对特定生物靶点的特殊结构。这些新化学实体（NCEs）为分子识别提供了见解，也可作为设计未来新药的先导物。本年度综述涵盖了2013年首次获批的24种新化学实体以及在上一版综述中未涉及的2种2012年获批药物的合成情况。
