Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
DNA Repair (Amst). 2014 May;17:39-51. doi: 10.1016/j.dnarep.2014.02.008. Epub 2014 Mar 14.
Double strand breaks pose unique problems for DNA repair, especially when broken ends possess complex structures that interfere with standard DNA transactions. Nonhomologous end joining can use multiple strategies to solve these problems. It further uses sophisticated means to ensure the strategy chosen provides the ideal balance of flexibility and accuracy.
双链断裂给 DNA 修复带来了独特的问题，尤其是当断裂末端具有复杂的结构，干扰标准的 DNA 转导时。非同源末端连接可以使用多种策略来解决这些问题。它进一步利用复杂的手段来确保所选择的策略提供了理想的灵活性和准确性之间的平衡。
