Martín-Cameán Ana, Molina-Villalba Isabel, Jos Angeles, Iglesias-Linares Alejandro, Solano Enrique, Cameán Ana M, Gil Fernando
Stomatology Department, School of Dentistry, University of Seville, Spain.
Department of Legal Medicine and Toxicology, Faculty of Medicine, University of Granada, Spain.
Environ Toxicol Pharmacol. 2014 Mar;37(2):759-71. doi: 10.1016/j.etap.2014.01.025. Epub 2014 Feb 13.
The study was aimed to assess Cu, Cr, Fe, Mn and Ni levels in human scalp hair from a broad population group treated with orthodontic appliances (n=70) to determine, whether the concentration of a given metal was significantly influenced by the orthodontic treatment in comparison to control group (n=56). Levels of metal compounds were determined by atomic absorption spectrometry. The mean, ranges, median and 5th and 95th percentiles of metals analyzed in hair that were hypothesized to be systemically absorbed from stainless steel, are provided. The influence of individual factors on metal concentrations was considered (gender, age), and inter-element interactions were studied by evaluation of correlation coefficients between elements, as well as by multiple regression analysis. Differences in the content of metals in hair were only significantly increased for Mn when compared to the control group, but their levels were of the same magnitude to other control populations, and consequently, no risks linked to the treatment have been found. The orthodontic treatment increased significantly Mn levels in young patients (<20 years old) when compared with control group. Scalp hair analysis is a good method to investigate the release of the elements from fixed orthodontic appliances.
该研究旨在评估接受正畸矫治器治疗的广泛人群组（n = 70）人头皮毛发中的铜、铬、铁、锰和镍水平，以确定与对照组（n = 56）相比，正畸治疗是否会显著影响特定金属的浓度。金属化合物的水平通过原子吸收光谱法测定。提供了假设从不锈钢中被全身吸收的毛发中分析的金属的平均值、范围、中位数以及第5和第95百分位数。考虑了个体因素（性别、年龄）对金属浓度的影响，并通过评估元素之间的相关系数以及多元回归分析来研究元素间的相互作用。与对照组相比，毛发中金属含量仅锰有显著增加，但其水平与其他对照人群相当，因此，未发现与治疗相关的风险。与对照组相比，正畸治疗使年轻患者（<20岁）的锰水平显著升高。头皮毛发分析是研究固定正畸矫治器中元素释放的良好方法。
