Mottaz J H, McKeever P J, Neveaux J L, Zelickson A S
Department of Dermatology, University of Minnesota Medical School, Minneapolis.
Int J Dermatol. 1988 Oct;27(8):596-600. doi: 10.1111/j.1365-4362.1988.tb02414.x.
Healthy adult (New Zealand, Dutch Belt, and Wild) rabbits were infected with rabbit papilloma virus (Shope variety). The resultant papillomas were treated with salicylic acid in a new transdermal drug delivery system utilizing a karaya gum glycol matrix. Biopsy samples of treated papillomas were taken at 1, 2, and 3 weeks after initiation of treatment and examined by electron microscopy. The observed changes during the course of treatment indicated that the karaya gum glycol matrix effectively released salicylic acid into the stratum corneum. Further, the rate of delivery of salicylic acid was such that the desired keratolytic activity was achieved with minimal inflammatory response.
健康成年（新西兰兔、荷兰带兔和野兔）兔子感染了兔乳头瘤病毒（肖普变种）。利用刺梧桐树胶二醇基质的新型透皮给药系统，用水杨酸对产生的乳头瘤进行治疗。在开始治疗后的第1、2和3周采集经治疗乳头瘤的活检样本，并通过电子显微镜检查。治疗过程中观察到的变化表明，刺梧桐树胶二醇基质有效地将水杨酸释放到角质层中。此外，水杨酸的释放速率使得在最小炎症反应的情况下实现了所需的角质溶解活性。
