1] Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics & Gynecology, IBS, Fudan University Shanghai Medical College, Shanghai, China [2] Department of Reproductive Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics & Gynecology, IBS, Fudan University Shanghai Medical College, Shanghai, China.
Cell Mol Immunol. 2014 May;11(3):253-62. doi: 10.1038/cmi.2013.67. Epub 2014 Mar 17.
T helper 17 (Th17) cells have both regulatory and protective roles in physiological conditions. The Th17 subset and the cytokine interleukin-17A (IL-17A) have been implicated in the pathogenesis of certain autoimmune diseases, several types of cancer and allograft rejection. However, the role of Th17 cells at the maternal/fetal interface remains unknown. Here, we demonstrate that Th17 cells are present in decidua and are increased in the peripheral blood of 10 clinically normal pregnancies based on intracellular cytokine analysis. Our results suggest a potential role of Th17 cells in sustaining pregnancy in humans. Furthermore, we demonstrate that decidual stromal cells (DSCs) but not trophoblast cells recruit peripheral Th17 cells into the decidua by secreting CCL2. The recruited Th17 cells promote proliferation and invasion and inhibit the apoptosis of human trophoblast cells by secreting IL-17 during the first trimester of pregnancy. These findings indicate a novel role for Th17 cells in controlling the maternal-fetal relationship and placenta development.
辅助性 T 细胞 17（Th17）在生理条件下具有调节和保护作用。Th17 亚群和细胞因子白细胞介素-17A（IL-17A）已被牵涉到某些自身免疫性疾病、多种类型的癌症和同种异体移植排斥反应的发病机制中。然而，Th17 细胞在母体/胎儿界面的作用仍不清楚。在这里，我们通过细胞内细胞因子分析表明，Th17 细胞存在于蜕膜中，并在 10 例临床正常妊娠的外周血中增加。我们的结果表明 Th17 细胞在维持人类妊娠中可能具有作用。此外，我们证明了蜕膜基质细胞（DSC）而不是滋养层细胞通过分泌 CCL2 将外周 Th17 细胞招募到蜕膜中。在妊娠早期，募集的 Th17 细胞通过分泌 IL-17 促进人滋养层细胞的增殖和侵袭，并抑制其凋亡。这些发现表明 Th17 细胞在控制母婴关系和胎盘发育方面具有新的作用。
