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相似文献

1
Autoimmune sequence of streptococcal M protein shared with the intermediate filament protein, vimentin.与中间丝蛋白波形蛋白共享的链球菌M蛋白的自身免疫序列。
J Exp Med. 1989 Feb 1;169(2):481-92. doi: 10.1084/jem.169.2.481.
2
Renal autoimmune epitope of group A streptococci specified by M protein tetrapeptide Ile-Arg-Leu-Arg.由M蛋白四肽异亮氨酸-精氨酸-亮氨酸-精氨酸确定的A组链球菌的肾脏自身免疫表位。
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4516-20. doi: 10.1073/pnas.85.12.4516.
3
Identification of an epitope of type 1 streptococcal M protein that is shared with a 43-kDa protein of human myocardium and renal glomeruli.鉴定1型链球菌M蛋白的一个表位，该表位与人心肌和肾小球的一种43 kDa蛋白共有。
J Immunol. 1990 Dec 15;145(12):4089-93.
4
Vimentin-cross-reactive epitope of type 12 streptococcal M protein.12型链球菌M蛋白的波形蛋白交叉反应表位
Infect Immun. 1989 Aug;57(8):2457-61. doi: 10.1128/iai.57.8.2457-2461.1989.
5
Intermediate filaments vimentin and desmin share epitopes with M 1 protein of group A streptococci.中间丝波形蛋白和结蛋白与A组链球菌的M1蛋白共有表位。
Zentralbl Bakteriol. 1990 Nov;274(2):183-94. doi: 10.1016/s0934-8840(11)80101-5.
6
Monoclonal antibody to human renal glomeruli cross-reacts with streptococcal M protein.抗人肾小球的单克隆抗体与链球菌M蛋白发生交叉反应。
Infect Immun. 1987 Oct;55(10):2416-9. doi: 10.1128/iai.55.10.2416-2419.1987.
7
Tropomyosin shares immunologic epitopes with group A streptococcal M proteins.
J Immunol. 1989 Apr 1;142(7):2475-81.
8
Epitopes of group A streptococcal M protein shared with antigens of articular cartilage and synovium.A组链球菌M蛋白的表位与关节软骨和滑膜抗原共有。
J Immunol. 1991 May 1;146(9):3132-7.
9
Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses, and human cardiac myosin.细胞毒性抗体和病毒中和抗体与链球菌M蛋白、肠道病毒及人心脏肌球蛋白发生交叉反应。
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1320-4. doi: 10.1073/pnas.89.4.1320.
10
A subset of mouse monoclonal antibodies cross-reactive with cytoskeletal proteins and group A streptococcal M proteins recognizes N-acetyl-beta-D-glucosamine.一组与细胞骨架蛋白和A组链球菌M蛋白发生交叉反应的小鼠单克隆抗体可识别N-乙酰-β-D-葡萄糖胺。
J Immunol. 1993 Oct 1;151(7):3902-13.

引用本文的文献

1
Otitis media: recent advances in otitis media vaccine development and model systems.中耳炎：中耳炎疫苗研发及模型系统的最新进展
Front Microbiol. 2024 Jan 24;15:1345027. doi: 10.3389/fmicb.2024.1345027. eCollection 2024.
2
Vimentin-cross-reactive epitope of type 12 streptococcal M protein.12型链球菌M蛋白的波形蛋白交叉反应表位
Infect Immun. 1989 Aug;57(8):2457-61. doi: 10.1128/iai.57.8.2457-2461.1989.
3
Cross-reactivity and sequence homology between the 65-kilodalton mycobacterial heat shock protein and human lactoferrin, transferrin, and DR beta subsets of major histocompatibility complex class II molecules.65千道尔顿分枝杆菌热休克蛋白与人类乳铁蛋白、转铁蛋白以及主要组织相容性复合体II类分子的DRβ亚群之间的交叉反应性和序列同源性。
Infect Immun. 1990 May;58(5):1461-70. doi: 10.1128/iai.58.5.1461-1470.1990.
4
Immunoreactivity of anti-streptococcal monoclonal antibodies to human heart valves. Evidence for multiple cross-reactive epitopes.抗链球菌单克隆抗体对人心脏瓣膜的免疫反应性。多个交叉反应表位的证据。
Am J Pathol. 1991 Feb;138(2):285-301.
5
Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses, and human cardiac myosin.细胞毒性抗体和病毒中和抗体与链球菌M蛋白、肠道病毒及人心脏肌球蛋白发生交叉反应。
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1320-4. doi: 10.1073/pnas.89.4.1320.

本文引用的文献

1
Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody.组织细胞中抗原的定位；通过荧光抗体检测抗原的方法的改进。
J Exp Med. 1950 Jan 1;91(1):1-13. doi: 10.1084/jem.91.1.1.
2
Current knowledge of type-specific M antigens of group A streptococci.A组链球菌特定类型M抗原的现有知识。
J Immunol. 1962 Sep;89:307-13.
3
Intermediate filaments as mechanical integrators of cellular space.中间丝作为细胞空间的机械整合器。
Nature. 1980 Jan 17;283(5744):249-256. doi: 10.1038/283249a0.
4
Streptococcal M protein: alpha-helical coiled-coil structure and arrangement on the cell surface.链球菌M蛋白：α-螺旋卷曲螺旋结构及其在细胞表面的排列
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4689-93. doi: 10.1073/pnas.78.8.4689.
5
Tropomyosin-like seven residue periodicity in three immunologically distinct streptococal M proteins and its implications for the antiphagocytic property of the molecule.三种免疫特性不同的链球菌M蛋白中类似原肌球蛋白的七残基周期性及其对该分子抗吞噬特性的影响。
J Exp Med. 1980 Mar 1;151(3):695-708. doi: 10.1084/jem.151.3.695.
6
Permanently proliferating rat vascular smooth muscle cell with maintained expression of smooth muscle characteristics, including actin of the vascular smooth muscle type.具有维持平滑肌特征表达的永久性增殖大鼠血管平滑肌细胞，包括血管平滑肌型肌动蛋白。
J Cell Biol. 1980 Dec;87(3 Pt 1):594-600. doi: 10.1083/jcb.87.3.594.
7
[Induction of glomerulonephritis using cultured mesangial cells in rats].
Nihon Jinzo Gakkai Shi. 1984 Jun;26(6):691-702.
8
Epitope-specific protective immunogenicity of chemically synthesized 13-, 18-, and 23-residue peptide fragments of streptococcal M protein.链球菌M蛋白化学合成的13、18和23个氨基酸残基肽片段的表位特异性保护性免疫原性。
Proc Natl Acad Sci U S A. 1984 Apr;81(7):2203-7. doi: 10.1073/pnas.81.7.2203.
9
Repeating covalent structure and protective immunogenicity of native and synthetic polypeptide fragments of type 24 streptococcal M protein. Mapping of protective and nonprotective epitopes with monoclonal antibodies.24型链球菌M蛋白天然及合成多肽片段的重复共价结构与保护性免疫原性。用单克隆抗体对保护性和非保护性表位进行定位。
J Biol Chem. 1983 Nov 10;258(21):13250-7.
10
Differentiation of cell types in the mammalian kidney by immunofluorescence microscopy using antibodies to intermediate filament proteins and desmoplakins.利用针对中间丝蛋白和桥粒斑蛋白的抗体，通过免疫荧光显微镜对哺乳动物肾脏中的细胞类型进行分化。
Histochemistry. 1983;77(3):365-94. doi: 10.1007/BF00490899.

与中间丝蛋白波形蛋白共享的链球菌M蛋白的自身免疫序列。

Autoimmune sequence of streptococcal M protein shared with the intermediate filament protein, vimentin.

作者信息

Kraus W, Ohyama K, Snyder D S, Beachey E H

机构信息

Veterans Administration Medical Center, Memphis, Tennessee.

出版信息

J Exp Med. 1989 Feb 1;169(2):481-92. doi: 10.1084/jem.169.2.481.

DOI:10.1084/jem.169.2.481
PMID:2463329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189220/
Abstract

The crossreactivity of antibodies against a renal autoimmune epitope of Streptococcus pyogenes M protein with glomerular mesangial cells was investigated. The antibodies directed against the amino acid sequence Ile-Arg-Leu-Arg of the nephritogenic type 1 M protein reacted in a fibrillar pattern with mesangial cells cultured from isolated glomeruli. In Western blots of urea-extracted mesangial proteins, the antibodies reacted with a 56-kD protein. Monoclonal and polyclonal antibodies identified the 56-kD mesangial protein as vimentin. Two synthetic peptides of human vimentin containing the sequence Arg-Leu-Arg reacted with the autoimmune antibodies raised against a streptococcal M protein peptide. These results provide evidence that the intermediate filament protein vimentin shares autoimmune epitopes with streptococcal M protein.

摘要

研究了抗化脓性链球菌M蛋白肾脏自身免疫表位的抗体与肾小球系膜细胞的交叉反应性。针对致肾炎1型M蛋白氨基酸序列Ile-Arg-Leu-Arg的抗体，与从分离的肾小球培养的系膜细胞呈纤维状反应。在尿素提取的系膜蛋白的蛋白质印迹法中，该抗体与一种56-kD蛋白发生反应。单克隆抗体和多克隆抗体将56-kD系膜蛋白鉴定为波形蛋白。两条含序列Arg-Leu-Arg的人波形蛋白合成肽，与针对链球菌M蛋白肽产生的自身免疫抗体发生反应。这些结果证明中间丝蛋白波形蛋白与链球菌M蛋白共享自身免疫表位。