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1
Identification of amino acids recognized by syncytium-inhibiting and neutralizing monoclonal antibodies to the human parainfluenza type 3 virus fusion protein.对人副流感3型病毒融合蛋白具有合胞体抑制和中和作用的单克隆抗体所识别的氨基酸的鉴定
J Virol. 1989 Sep;63(9):3755-60. doi: 10.1128/JVI.63.9.3755-3760.1989.
2
Antigenic and functional organization of human parainfluenza virus type 3 fusion glycoprotein.人副流感病毒3型融合糖蛋白的抗原性和功能组织
J Virol. 1989 Jan;63(1):375-82. doi: 10.1128/JVI.63.1.375-382.1989.
3
Antibody responses of humans and nonhuman primates to individual antigenic sites of the hemagglutinin-neuraminidase and fusion glycoproteins after primary infection or reinfection with parainfluenza type 3 virus.人类和非人类灵长类动物在初次感染或再次感染3型副流感病毒后，针对血凝素神经氨酸酶和融合糖蛋白的各个抗原位点的抗体反应。
J Virol. 1990 Aug;64(8):3833-43. doi: 10.1128/JVI.64.8.3833-3843.1990.
4
Naturally occurring human parainfluenza type 3 viruses exhibit divergence in amino acid sequence of their fusion protein neutralization epitopes and cleavage sites.天然存在的人副流感3型病毒在其融合蛋白中和表位和裂解位点的氨基酸序列上存在差异。
J Virol. 1990 Mar;64(3):1329-34. doi: 10.1128/JVI.64.3.1329-1334.1990.
5
Characterization of two antigenic sites recognized by neutralizing monoclonal antibodies directed against the fusion glycoprotein of human respiratory syncytial virus.针对人呼吸道合胞病毒融合糖蛋白的中和性单克隆抗体所识别的两个抗原位点的特性分析
J Gen Virol. 1992 Sep;73 ( Pt 9):2225-34. doi: 10.1099/0022-1317-73-9-2225.
6
Identification of amino acids relevant to three antigenic determinants on the fusion protein of Newcastle disease virus that are involved in fusion inhibition and neutralization.鉴定与新城疫病毒融合蛋白上三个抗原决定簇相关的氨基酸，这些抗原决定簇参与融合抑制和中和作用。
J Virol. 1988 Nov;62(11):4427-30. doi: 10.1128/JVI.62.11.4427-4430.1988.
7
The fusion glycoprotein of Sendai virus: sequence analysis of an epitope involved in fusion and virus neutralization.
Virology. 1987 Apr;157(2):556-9. doi: 10.1016/0042-6822(87)90301-1.
8
Extensive antigenic diversity among human parainfluenza type 2 virus isolates and immunological relationships among paramyxoviruses revealed by monoclonal antibodies.通过单克隆抗体揭示的人副流感病毒2型分离株之间广泛的抗原多样性以及副粘病毒之间的免疫关系。
Virology. 1989 Jul;171(1):38-48. doi: 10.1016/0042-6822(89)90508-4.
9
Mutations located on both F1 and F2 subunits of the Newcastle disease virus fusion protein confer resistance to neutralization with monoclonal antibodies.新城疫病毒融合蛋白的F1和F2亚基上的突变赋予了对单克隆抗体中和作用的抗性。
J Virol. 1989 Feb;63(2):952-4. doi: 10.1128/JVI.63.2.952-954.1989.
10
Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein.用呼吸道合胞病毒中和性人抗体Fab片段（Fab 19）筛选出的单克隆抗体抗性突变体在融合（F）糖蛋白上定义了一个独特的表位。
Virology. 1998 Dec 20;252(2):373-5. doi: 10.1006/viro.1998.9462.

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Molecular Evolution of the () Genes in Human Parainfluenza Virus Type 2.人副流感病毒2型（ ）基因的分子进化
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Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies.人源单克隆抗体对3型人副流感病毒中和作用的功能和结构基础
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Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.多种病毒的成熟和传播都需要钙转运蛋白 SPCA1。
Cell Host Microbe. 2017 Oct 11;22(4):460-470.e5. doi: 10.1016/j.chom.2017.09.002.
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Sequence motifs and prokaryotic expression of the reptilian paramyxovirus fusion protein.爬行动物副粘病毒融合蛋白的序列基序与原核表达
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Antigenic structure of human respiratory syncytial virus fusion glycoprotein.人类呼吸道合胞病毒融合糖蛋白的抗原结构
J Virol. 1998 Aug;72(8):6922-8. doi: 10.1128/JVI.72.8.6922-6928.1998.
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Assignment of disulfide bridges in the fusion glycoprotein of Sendai virus.仙台病毒融合糖蛋白中二硫键的定位
J Virol. 1994 May;68(5):3200-6. doi: 10.1128/JVI.68.5.3200-3206.1994.
7
Measles virus fusion: role of the cysteine-rich region of the fusion glycoprotein.麻疹病毒融合：融合糖蛋白富含半胱氨酸区域的作用
J Virol. 1994 Nov;68(11):7546-8. doi: 10.1128/JVI.68.11.7546-7548.1994.
8
Contribution of measles virus fusion protein in protective immunity: anti-F monoclonal antibodies neutralize virus infectivity and protect mice against challenge.麻疹病毒融合蛋白在保护性免疫中的作用：抗F单克隆抗体中和病毒感染性并保护小鼠免受攻击。
J Virol. 1990 Oct;64(10):5160-2. doi: 10.1128/JVI.64.10.5160-5162.1990.
9
Naturally occurring human parainfluenza type 3 viruses exhibit divergence in amino acid sequence of their fusion protein neutralization epitopes and cleavage sites.天然存在的人副流感3型病毒在其融合蛋白中和表位和裂解位点的氨基酸序列上存在差异。
J Virol. 1990 Mar;64(3):1329-34. doi: 10.1128/JVI.64.3.1329-1334.1990.

本文引用的文献

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Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequences similar to those at the N-termini of the F1 or HA2 viral polypeptides.具有与F1或HA2病毒多肽N端氨基酸序列相似的氨基酸序列的寡肽对副粘病毒和粘液病毒复制的特异性抑制作用。
Virology. 1980 Aug;105(1):205-22. doi: 10.1016/0042-6822(80)90168-3.
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Oligopeptides that specifically inhibit membrane fusion by paramyxoviruses: studies on the site of action.特异性抑制副粘病毒膜融合的寡肽：作用位点研究
Virology. 1983 Dec;131(2):518-32. doi: 10.1016/0042-6822(83)90517-2.
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Activation of the Sendai virus fusion protein (f) involves a conformational change with exposure of a new hydrophobic region.仙台病毒融合蛋白（F）的激活涉及构象变化以及新疏水区域的暴露。
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Three-dimensional structure of an antigenic mutant of the influenza virus haemagglutinin.流感病毒血凝素抗原突变体的三维结构
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Use of hybridoma monoclonal antibodies in the detection of antigenic differences between rabies and rabies-related virus proteins. II. The glycoprotein.杂交瘤单克隆抗体在检测狂犬病病毒与狂犬病相关病毒蛋白抗原差异中的应用。II. 糖蛋白。
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Acquisition of serum antibodies to specific viral glycoproteins of parainfluenza virus 3 in children.儿童血清中针对副流感病毒3型特定病毒糖蛋白的抗体获取情况。
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Identification of biological activities of paramyxovirus glycoproteins. Activation of cell fusion, hemolysis, and infectivity of proteolytic cleavage of an inactive precursor protein of Sendai virus.副粘病毒糖蛋白生物活性的鉴定。仙台病毒无活性前体蛋白经蛋白水解切割后细胞融合、溶血及感染性的激活。
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Immunological differences between the envelope glycoproteins of two strains of human respiratory syncytial virus.两株人呼吸道合胞病毒包膜糖蛋白之间的免疫学差异
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Ability of the hydrophobic fusion-related external domain of a paramyxovirus F protein to act as a membrane anchor.副粘病毒F蛋白疏水融合相关外部结构域作为膜锚定物的能力。
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对人副流感3型病毒融合蛋白具有合胞体抑制和中和作用的单克隆抗体所识别的氨基酸的鉴定

Identification of amino acids recognized by syncytium-inhibiting and neutralizing monoclonal antibodies to the human parainfluenza type 3 virus fusion protein.

作者信息

Coelingh K V, Tierney E L

机构信息

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.

出版信息

J Virol. 1989 Sep;63(9):3755-60. doi: 10.1128/JVI.63.9.3755-3760.1989.

DOI:10.1128/JVI.63.9.3755-3760.1989
PMID:2474672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC250967/
Abstract

Neutralizing monoclonal antibodies specific for the fusion (F) glycoprotein of human parainfluenza type 3 virus (PIV3) were used to select neutralization-resistant antigenic variants. Sequence analysis of the F genes of the variants indicated that their resistance to antibody binding, antibody-mediated neutralization or to both was a result of specific amino acid substitutions within the neutralization epitopes of the F1 and F2 subunits. Comparison of the locations of PIV3 neutralization epitopes with those of Newcastle disease and Sendai viruses indicated that the antigenic organization of the fusion proteins of paramyxoviruses is similar. Furthermore, some of the PIV3 epitopes recognized by syncytium-inhibiting monoclonal antibodies are located in an F1 cysteine cluster region which corresponds to an area of the measles virus F protein involved in fusion activity.

摘要

使用针对人副流感3型病毒（PIV3）融合（F）糖蛋白的中和单克隆抗体来筛选抗中和抗原变体。对这些变体的F基因进行序列分析表明，它们对抗体结合、抗体介导的中和或两者的抗性是F1和F2亚基中和表位内特定氨基酸取代的结果。将PIV3中和表位的位置与新城疫病毒和仙台病毒的位置进行比较表明，副粘病毒融合蛋白的抗原结构相似。此外，一些被抑制合胞体的单克隆抗体识别的PIV3表位位于F1半胱氨酸簇区域，该区域对应于麻疹病毒F蛋白参与融合活性的区域。