Slimani Samy, Abbas Abdelmalek, Ben Ammar Amina, Kebaili Djemaa, Ali El Hadi, Rahal Fadia, Khamari Mohamed Choukri, Baltache Ayada, Khider Imene, Chiheub Riad, Khelif Khireddine, Akbi Sabrina, Rahmani Salima, Dahou-Makhloufi Chafia, Brahimi-Mazouni Nadjia, Abtroun-Benmadi Sabira, Ladjouze-Rezig Aicha
Department of Medicine, Hadj Lakhdar University, Batna, Algeria,
Rheumatol Int. 2014 Sep;34(9):1235-9. doi: 10.1007/s00296-014-2981-7. Epub 2014 Mar 15.
The aim of this study was to compare the epidemiology of rheumatoid arthritis (RA) in North Africa to that of Western countries. We have enrolled in a cross-sectional study all consecutive patients presenting with the diagnosis of RA according to the 1987 ACR criteria, and during a 5-month period, patients were included in 11 centers across northern Algeria. Demographics, clinical data, and health assessment questionnaires (HAQ) were collected for each patient. We have estimated means, standard deviations, and 95 % confidence intervals for all parameters. Of the 249 patients (213 females and 36 males) enrolled in the study, 10 (4 %) had juvenile onset of the disease. The mean age was 50.1 ± 14.5 years, and the mean duration of RA was 8.4 ± 7.8 years. In terms of comorbidities, 18.9 % of patients reported hypertension and 5.2 % had diabetes. The mean DAS28 at inclusion was 4.3 (95 % CI 4.1-4.5); 14.0 % were in remission (DAS28 ≤ 2.6). The mean HAQ score was 0.81 ± 0.82. Rheumatoid factor was positive in 78.5 % of cases, and anti-citrullinated protein/peptide antibodies, when measured, was positive in 69.0 % of cases. Seronegative patients were older and had a relatively less severe disease. For treatment, 89.7 % of patients were taking disease-modifying anti-rheumatic drugs and only 4 % were taking biologics (rituximab); 90.8 % of patients were taking glucocorticoids, and none of the patients satisfied the recommended calcium intake guidelines. RA in Algeria is more common in women. Compared to reports from Western countries, RA in Algeria appears to be less aggressive, with more dominant seronegative oligoarthritis forms. The remission rate is comparable to that of Western populations.
本研究的目的是比较北非类风湿关节炎（RA）的流行病学与西方国家的情况。我们开展了一项横断面研究，纳入了所有根据1987年美国风湿病学会（ACR）标准确诊为RA的连续患者，在5个月的时间里，阿尔及利亚北部11个中心纳入了患者。收集了每位患者的人口统计学信息、临床数据和健康评估问卷（HAQ）。我们估算了所有参数的均值、标准差和95%置信区间。在纳入研究的249例患者（213例女性和36例男性）中，10例（4%）为青少年发病。平均年龄为50.1±14.5岁，RA的平均病程为8.4±7.8年。就合并症而言，18.9%的患者报告有高血压，5.2%患有糖尿病。纳入时的平均疾病活动度评分（DAS28）为4.3（95%CI 4.1 - 4.5）；14.0%处于缓解期（DAS28≤2.6）。平均HAQ评分为0.81±0.82。类风湿因子在78.5%的病例中呈阳性，抗瓜氨酸化蛋白/肽抗体检测时，在69.0%的病例中呈阳性。血清学阴性患者年龄较大，疾病相对较轻。在治疗方面，89.7%的患者正在服用改善病情抗风湿药物，只有4%的患者正在使用生物制剂（利妥昔单抗）；90.8%的患者正在服用糖皮质激素，没有患者达到推荐的钙摄入量指南。阿尔及利亚的RA在女性中更为常见。与西方国家的报告相比，阿尔及利亚的RA似乎侵袭性较小，血清学阴性寡关节炎形式更为常见。缓解率与西方人群相当。
