Department of Psychology, Kent State University, Kent, Ohio 44242, USA.
Learn Mem. 2014 Mar 14;21(4):180-4. doi: 10.1101/lm.032961.113.
Though much attention has been given to the neural structures that underlie the long-term consolidation of contextual memories, little is known about the mechanisms responsible for the maintenance of memory precision. Here, we demonstrate a rapid time-dependent decline in memory precision in GABAB(1a) receptor knockout mice. First, we show that GABAB(1a) receptors are required for the maintenance, but not encoding, of a precise fear memory. We then demonstrate that GABAB(1a) receptors are required for the maintenance, but not encoding, of spatial memories. Our findings suggest that GABA-mediated presynaptic inhibition regulates the maintenance of memory precision as a function of memory age.
尽管人们对基础上下文记忆的长期巩固的神经结构给予了大量关注，但对于负责维持记忆精度的机制却知之甚少。在这里，我们证明了 GABAB(1a) 受体敲除小鼠的记忆精度会迅速随时间下降。首先，我们表明 GABAB(1a) 受体对于维持而不是编码精确的恐惧记忆是必需的。然后，我们证明 GABAB(1a) 受体对于维持而不是编码空间记忆是必需的。我们的发现表明，GABA 介导的突触前抑制调节记忆精度的维持，作为记忆年龄的函数。
