胶质瘤中的癌症干细胞：挑战与机遇
Cancer stem cells in glioma: challenges and opportunities.
作者信息
Wang Jialiang, Ma Yufang, Cooper Michael K
机构信息
Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA ; Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
出版信息
Transl Cancer Res. 2013 Oct 1;2(5):429-441. doi: 10.3978/j.issn.2218-676X.2013.08.01.
Abstract
The discovery of cancer stem cells in glioma has created a paradigm shift in our understanding of this deadly disease. Glioma stem cells exhibit sustained self-renewal and potent tumorigenic potential and differ from their more differentiated progeny in response to current therapies. Recurrent disease is likely derived from glioma stem cells or progeny reprogrammed to gain stem cell-like phenotypes, indicating that the stem cell phenotype is a crucial therapeutic target. While debate over cancer stem cell and clonal evolution models persists, important knowledge has been gained over the past decade from glioma stem cells investigation and clinical impact is expected.
摘要
胶质瘤中癌症干细胞的发现，使我们对这种致命疾病的理解发生了范式转变。胶质瘤干细胞表现出持续的自我更新能力和强大的致瘤潜力，并且在对当前治疗的反应上与其分化程度更高的子代细胞有所不同。复发性疾病很可能源自胶质瘤干细胞或重新编程以获得干细胞样表型的子代细胞，这表明干细胞表型是一个关键的治疗靶点。尽管关于癌症干细胞和克隆进化模型的争论仍在继续，但在过去十年中，通过对胶质瘤干细胞的研究已经获得了重要知识，并且有望产生临床影响。
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