Greider C W, Blackburn E H
Cold Spring Harbor Laboratory, New York 11724.
Nature. 1989 Jan 26;337(6205):331-7. doi: 10.1038/337331a0.
The telomerase enzyme of Tetrahymena synthesizes repeats of the telomeric DNA sequence TTGGGG de novo in the absence of added template. The essential RNA component of this ribonucleoprotein enzyme has now been cloned and found to contain the sequence CAACCCCAA, which seems to be the template for the synthesis of TTGGGG repeats.
嗜热四膜虫的端粒酶在没有添加模板的情况下能从头合成端粒DNA序列TTGGGG的重复序列。这种核糖核蛋白酶的必需RNA组分现已被克隆，发现其含有序列CAACCCCAA，该序列似乎是合成TTGGGG重复序列的模板。
