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对小鼠CD2具有特异性的单克隆抗体表明，它存在于B细胞和T细胞上。

Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells.

作者信息

Yagita H, Nakamura T, Karasuyama H, Okumura K

机构信息

Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.

出版信息

Proc Natl Acad Sci U S A. 1989 Jan;86(2):645-9. doi: 10.1073/pnas.86.2.645.

DOI:10.1073/pnas.86.2.645
PMID:2463634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC286529/
Abstract

Monoclonal antibodies specific for the murine CD2 antigen were identified by an efficient screening method utilizing murine CD2 cDNA transfectants. An unexpected expression of CD2 on murine B cells was revealed by immunofluorescence and immunoprecipitation studies with these monoclonal antibodies and by RNA blot analysis for the murine CD2 transcript.

摘要

利用小鼠CD2 cDNA转染细胞，通过一种高效筛选方法鉴定出了对小鼠CD2抗原具有特异性的单克隆抗体。用这些单克隆抗体进行免疫荧光和免疫沉淀研究，以及对小鼠CD2转录本进行RNA印迹分析，结果显示小鼠B细胞上意外地表达了CD2。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/b3d6535440df/pnas00242-0250-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/a49dc6b42738/pnas00242-0249-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/e9182a0f0855/pnas00242-0249-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/f79fccfabb6e/pnas00242-0249-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/083bea603354/pnas00242-0249-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/9c4ef72b1ad9/pnas00242-0250-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/b3d6535440df/pnas00242-0250-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/a49dc6b42738/pnas00242-0249-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/e9182a0f0855/pnas00242-0249-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/f79fccfabb6e/pnas00242-0249-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/083bea603354/pnas00242-0249-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/9c4ef72b1ad9/pnas00242-0250-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/77d5/286529/b3d6535440df/pnas00242-0250-b.jpg

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本文引用的文献

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B220: a B cell-specific member of th T200 glycoprotein family.B220：T200糖蛋白家族的一种B细胞特异性成员。
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Identification of a human T lymphocyte surface protein associated with the E-rosette receptor.一种与E花环受体相关的人类T淋巴细胞表面蛋白的鉴定。
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Regulation of CXCL-8 (interleukin-8) induction by double-stranded RNA signaling pathways during hepatitis C virus infection.丙型肝炎病毒感染期间双链RNA信号通路对CXCL-8（白细胞介素-8）诱导的调控
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