对小鼠CD2具有特异性的单克隆抗体表明，它存在于B细胞和T细胞上。
Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells.
作者信息
Yagita H, Nakamura T, Karasuyama H, Okumura K
机构信息
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
出版信息
Proc Natl Acad Sci U S A. 1989 Jan;86(2):645-9. doi: 10.1073/pnas.86.2.645.
Abstract
Monoclonal antibodies specific for the murine CD2 antigen were identified by an efficient screening method utilizing murine CD2 cDNA transfectants. An unexpected expression of CD2 on murine B cells was revealed by immunofluorescence and immunoprecipitation studies with these monoclonal antibodies and by RNA blot analysis for the murine CD2 transcript.
摘要
利用小鼠CD2 cDNA转染细胞，通过一种高效筛选方法鉴定出了对小鼠CD2抗原具有特异性的单克隆抗体。用这些单克隆抗体进行免疫荧光和免疫沉淀研究，以及对小鼠CD2转录本进行RNA印迹分析，结果显示小鼠B细胞上意外地表达了CD2。
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