Boley Nathan, Wan Kenneth H, Bickel Peter J, Celniker Susan E
Department of Biostatistics, University of California Berkeley, Berkeley, CA, United States.
Department of Genome Dynamics, Lawrence Berkeley National Laboratory, Berkeley, CA, United States.
Methods. 2014 Jun 15;68(1):38-47. doi: 10.1016/j.ymeth.2014.03.007. Epub 2014 Mar 15.
modENCODE was a 5year NHGRI funded project (2007-2012) to map the function of every base in the genomes of worms and flies characterizing positions of modified histones and other chromatin marks, origins of DNA replication, RNA transcripts and the transcription factor binding sites that control gene expression. Here we describe the Drosophila modENCODE datasets and how best to access and use them for genome wide and individual gene studies.
modENCODE是美国国立人类基因组研究所资助的一个为期5年的项目（2007 - 2012年），旨在绘制蠕虫和果蝇基因组中每个碱基的功能图谱，确定修饰组蛋白和其他染色质标记的位置、DNA复制起点、RNA转录本以及控制基因表达的转录因子结合位点。在这里，我们描述了果蝇modENCODE数据集，以及如何最好地获取和使用这些数据集进行全基因组和单个基因的研究。
