Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Quebec H2W 1R7, Canada;
Genes Dev. 2014 Mar 15;28(6):533-47. doi: 10.1101/gad.236349.113.
Rho GTPases play key regulatory roles in many aspects of embryonic development, regulating processes such as differentiation, proliferation, morphogenesis, and migration. Two families of guanine nucleotide exchange factors (GEFs) found in metazoans, Dbl and Dock, are responsible for the spatiotemporal activation of Rac and Cdc42 proteins and their downstream signaling pathways. This review focuses on the emerging roles of the mammalian DOCK family in development and disease. We also discuss, when possible, how recent discoveries concerning the biological functions of these GEFs might be exploited for the development of novel therapeutic strategies.
Rho GTPases 在胚胎发育的许多方面发挥关键的调节作用，调节分化、增殖、形态发生和迁移等过程。真核生物中存在的两类鸟嘌呤核苷酸交换因子（GEFs），Dbl 和 Dock，负责 Rac 和 Cdc42 蛋白及其下游信号通路的时空激活。本综述重点介绍哺乳动物 DOCK 家族在发育和疾病中的新兴作用。我们还讨论了，在可能的情况下，这些 GEF 的生物学功能的最新发现如何被用于开发新的治疗策略。
