Department of Obstetrics and Gynecology and the Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch, Galveston, TX 77555-0587, United States.
Department of Obstetrics and Gynecology and the Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch, Galveston, TX 77555-0587, United States.
Vaccine. 2014 May 1;32(21):2394-8. doi: 10.1016/j.vaccine.2014.02.097. Epub 2014 Mar 15.
Geographic variation in provider-verified human papillomavirus (HPV) vaccine uptake among adolescent girls in the US has not been examined. To investigate this, we analyzed 2011 National Immunization Survey-Teen data. Among 13-17 year old girls (n=11,236), weighted vaccine initiation (48.4%) and completion rates (30.6%) were the lowest in the South when compared to the Northeast (53.4% and 39.9%), Midwest (51.1% and 33.5%) and West (61.6% and 38.7%) (P<.001, both for initiation and completion). Multivariable log-binomial regression analysis indicated that 13-17 year old girls living in the South were less likely to initiate [adjusted prevalence ratio (aPR)=0.86, 95% confidence interval (CI) 0.75-0.97] and complete (aPR=0.83, 95% CI, 0.74-0.93) the HPV vaccine series compared to girls living in the Northeast. Similar differences were observed when the uptake rates in the South were compared to other regions in the US. Intervention programs to increase HPV vaccine uptake and reduce regional disparities are warranted.
美国青少年女孩中，医疗服务提供者验证的人乳头瘤病毒（HPV）疫苗接种率存在地域差异，但目前尚未对此进行研究。为了调查这一情况，我们分析了 2011 年国家免疫调查-青少年的数据。在 13-17 岁的女孩中（n=11236），与东北部（53.4%和 39.9%）、中西部（51.1%和 33.5%）和西部（61.6%和 38.7%）相比，南部女孩的疫苗接种起始率（48.4%）和完成率（30.6%）最低（均<.001，起始和完成率）。多变量二项式log 回归分析表明，与东北部的女孩相比，南部 13-17 岁的女孩接种 HPV 疫苗系列的起始率[调整后患病率比（aPR）=0.86，95%置信区间（CI）0.75-0.97]和完成率（aPR=0.83，95%CI，0.74-0.93）均较低。当将南部的接种率与美国其他地区进行比较时，也观察到了类似的差异。需要开展干预项目，以提高 HPV 疫苗接种率，减少地域差异。
