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质量控制：局部 mRNA 是否有质量控制？

Quality control: Is there quality control of localized mRNAs?

机构信息

Department of Chemistry and Biochemistry and Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309.

出版信息

J Cell Biol. 2014 Mar 17;204(6):863-8. doi: 10.1083/jcb.201401059.

DOI:10.1083/jcb.201401059
PMID:24637320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3998798/
Abstract

In eukaryotic cells many mRNAs are localized to specific regions of the cytosol, thereby allowing the local production of proteins. The process of mRNA localization can be coordinated with mRNA turnover, which can also be spatially controlled to increase the degree of mRNA localization. The coordination of mRNA localization, translation repression during transport, and mRNA degradation suggests the hypothesis that an additional layer of mRNA quality control exists in cells to degrade mRNAs that fail to be appropriately localized.

摘要

在真核细胞中，许多 mRNA 定位于细胞质的特定区域，从而允许局部产生蛋白质。mRNA 定位的过程可以与 mRNA 周转相协调，也可以进行空间控制以增加 mRNA 定位的程度。mRNA 定位、运输过程中的翻译抑制和 mRNA 降解的协调表明，细胞中存在额外的 mRNA 质量控制层，以降解未能适当定位的 mRNA。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c23/3998798/fe8b33a44048/JCB_201401059_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c23/3998798/529883453236/JCB_201401059R_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c23/3998798/6872d30eb4b2/JCB_201401059_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c23/3998798/fe8b33a44048/JCB_201401059_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c23/3998798/529883453236/JCB_201401059R_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c23/3998798/6872d30eb4b2/JCB_201401059_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c23/3998798/fe8b33a44048/JCB_201401059_Fig3.jpg

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