RGG 基序蛋白：mRNA 功能状态的调节剂。
RGG motif proteins: modulators of mRNA functional states.
机构信息
Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, The University of Arizona, Tucson, Tucson, AZ, USA.
出版信息
Cell Cycle. 2012 Jul 15;11(14):2594-9. doi: 10.4161/cc.20716.
Abstract
A recent report demonstrates that a subset of RGG-motif proteins can bind translation initiation factor eIF4G and repress mRNA translation. This adds to the growing number of roles RGG-motif proteins play in modulating transcription, splicing, mRNA export and now translation. Herein, we review the nature and breadth of functions of RGG-motif proteins. In addition, the interaction of some RGG-motif proteins and other translation repressors with eIF4G highlights the role of eIF4G as a general modulator of mRNA function and not solely as a translation initiation factor.
摘要
最近的一份报告表明，RGG 基序蛋白的一个亚组可以结合翻译起始因子 eIF4G 并抑制 mRNA 翻译。这增加了 RGG 基序蛋白在调节转录、剪接、mRNA 输出以及现在的翻译中发挥作用的数量。在此，我们回顾了 RGG 基序蛋白的性质和广泛的功能。此外，一些 RGG 基序蛋白和其他翻译抑制剂与 eIF4G 的相互作用突出了 eIF4G 作为 mRNA 功能的一般调节剂的作用，而不仅仅是作为翻译起始因子。
相似文献
1
RGG motif proteins: modulators of mRNA functional states.RGG 基序蛋白：mRNA 功能状态的调节剂。
Cell Cycle. 2012 Jul 15;11(14):2594-9. doi: 10.4161/cc.20716.
2
RGG-motif self-association regulates eIF4G-binding translation repressor protein Scd6.RGG 基序自组装调节 eIF4G 结合翻译阻遏蛋白 Scd6。
RNA Biol. 2019 Sep;16(9):1215-1227. doi: 10.1080/15476286.2019.1621623. Epub 2019 Jun 12.
3
Scd6 targets eIF4G to repress translation: RGG motif proteins as a class of eIF4G-binding proteins.Scd6 通过靶向 eIF4G 来抑制翻译：RGG 基序蛋白作为一类 eIF4G 结合蛋白。
Mol Cell. 2012 Jan 27;45(2):244-54. doi: 10.1016/j.molcel.2011.11.026.
4
RGG-motif containing mRNA export factor Gbp2 acts as a translation repressor.富含 RGG 基序的 mRNA 输出因子 Gbp2 作为翻译抑制剂发挥作用。
RNA Biol. 2021 Dec;18(12):2342-2353. doi: 10.1080/15476286.2021.1910403. Epub 2021 Apr 29.
5
The histone 3'-terminal stem-loop-binding protein enhances translation through a functional and physical interaction with eukaryotic initiation factor 4G (eIF4G) and eIF3.组蛋白3'末端茎环结合蛋白通过与真核起始因子4G（eIF4G）和eIF3的功能及物理相互作用增强翻译。
Mol Cell Biol. 2002 Nov;22(22):7853-67. doi: 10.1128/MCB.22.22.7853-7867.2002.
6
Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.eIF4G 和 4E-BPs 中的结构基序调节它们与 eIF4E 的结合，从而调节酵母中的翻译起始。
Nucleic Acids Res. 2018 Jul 27;46(13):6893-6908. doi: 10.1093/nar/gky542.
7
The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation.4E-BP Caf20p介导eIF4E依赖和独立的翻译抑制。
PLoS Genet. 2015 May 14;11(5):e1005233. doi: 10.1371/journal.pgen.1005233. eCollection 2015 May.
8
Accumulation of polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae.酿酒酵母中多聚腺苷酸化mRNA、Pab1p、eIF4E和eIF4G与P小体的积累。
Mol Biol Cell. 2007 Jul;18(7):2592-602. doi: 10.1091/mbc.e06-12-1149. Epub 2007 May 2.
9
eIF4F is a thermo-sensing regulatory node in the translational heat shock response.真核翻译起始因子 4F 是翻译热休克反应中的热敏调节节点。
Mol Cell. 2024 May 2;84(9):1727-1741.e12. doi: 10.1016/j.molcel.2024.02.038. Epub 2024 Mar 27.
10
Tdh3 and Rom2 are functional modulators of a conserved condensate-resident RNA-binding protein, Scd6, in Saccharomyces cerevisiae.Tdh3 和 Rom2 是酿酒酵母中一种保守的凝聚物驻留 RNA 结合蛋白 Scd6 的功能调节剂。
Genetics. 2024 Oct 7;228(2). doi: 10.1093/genetics/iyae127.
引用本文的文献
1
PRMT1 oligomerization regulates RNA-binding protein cascade to promote pancreatic cancer.蛋白质精氨酸甲基转移酶1（PRMT1）的寡聚化调节RNA结合蛋白级联反应以促进胰腺癌。
Life Sci Alliance. 2025 Jul 17;8(9). doi: 10.26508/lsa.202503202. Print 2025 Sep.
2
Decoding the interactions and functions of non-coding RNA with artificial intelligence.利用人工智能解码非编码RNA的相互作用和功能。
Nat Rev Mol Cell Biol. 2025 Jun 19. doi: 10.1038/s41580-025-00857-w.
3
Expression of spider silk protein in tobacco improves drought tolerance with minimal effects on its mechanotype.蜘蛛丝蛋白在烟草中的表达提高了耐旱性，对其机械类型影响最小。
Plant J. 2025 Jan;121(2):e17213. doi: 10.1111/tpj.17213.
4
PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells.PRMT5 介导的 FXR1 精氨酸甲基化对于癌细胞中的 RNA 结合至关重要。
Nucleic Acids Res. 2024 Jul 8;52(12):7225-7244. doi: 10.1093/nar/gkae319.
5
Adenosine Triphosphate: The Primordial Molecule That Controls Protein Homeostasis and Shapes the Genome-Proteome Interface.三磷酸腺苷：控制蛋白质稳态并塑造基因组 - 蛋白质组界面的原始分子。
Biomolecules. 2024 Apr 19;14(4):500. doi: 10.3390/biom14040500.
6
Protein arginine methylation in viral infection and antiviral immunity.病毒感染与抗病毒免疫中的蛋白质精氨酸甲基化。
Int J Biol Sci. 2023 Oct 24;19(16):5292-5318. doi: 10.7150/ijbs.89498. eCollection 2023.
7
Citrullination and the protein code: crosstalk between post-translational modifications in cancer.瓜氨酸化与蛋白质编码：癌症中翻译后修饰的串扰。
Philos Trans R Soc Lond B Biol Sci. 2023 Nov 20;378(1890):20220243. doi: 10.1098/rstb.2022.0243. Epub 2023 Oct 2.
8
Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis.插入序列2基序的保守性赋予不同物种的Rev1破坏G-四链体并刺激跨损伤DNA合成的能力。
RSC Chem Biol. 2023 May 11;4(7):466-485. doi: 10.1039/d3cb00027c. eCollection 2023 Jul 5.
9
piRNA pathway evolution beyond gonad context: Perspectives from apicomplexa and trypanosomatids.性腺环境之外的piRNA通路进化：来自顶复门原虫和锥虫的视角
Front Genet. 2023 Feb 3;14:1129194. doi: 10.3389/fgene.2023.1129194. eCollection 2023.
10
Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA.Npl3 通过将 mRNP 组件招募到转录位点并将其转移到 mRNA 上来发挥作用。
Nucleic Acids Res. 2023 Jan 25;51(2):831-851. doi: 10.1093/nar/gkac1206.
本文引用的文献
1
Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2.Wnt3a 刺激的 LRP6 磷酸化依赖于 G3BP2 的精氨酸甲基化。
J Cell Sci. 2012 May 15;125(Pt 10):2446-56. doi: 10.1242/jcs.100933. Epub 2012 Feb 22.
2
Scd6 targets eIF4G to repress translation: RGG motif proteins as a class of eIF4G-binding proteins.Scd6 通过靶向 eIF4G 来抑制翻译：RGG 基序蛋白作为一类 eIF4G 结合蛋白。
Mol Cell. 2012 Jan 27;45(2):244-54. doi: 10.1016/j.molcel.2011.11.026.
3
mRNA translation and energy metabolism in cancer: the role of the MAPK and mTORC1 pathways.癌症中的mRNA翻译与能量代谢：MAPK和mTORC1信号通路的作用
Cold Spring Harb Symp Quant Biol. 2011;76:355-67. doi: 10.1101/sqb.2011.76.010785. Epub 2011 Nov 28.
4
The Role of Protein Arginine Methylation in mRNP Dynamics.蛋白质精氨酸甲基化在信使核糖核蛋白动态变化中的作用
Mol Biol Int. 2011;2011:163827. doi: 10.4061/2011/163827. Epub 2011 Apr 7.
5
The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.Edc3 和 Scd6 介导的 Dcp1:Dcp2 mRNA 脱帽复合物激活的结构基础。
EMBO J. 2012 Jan 18;31(2):279-90. doi: 10.1038/emboj.2011.408. Epub 2011 Nov 15.
6
Local RNA translation at the synapse and in disease.突触处及疾病中的局部 RNA 翻译。
J Neurosci. 2011 Nov 9;31(45):16086-93. doi: 10.1523/JNEUROSCI.4105-11.2011.
7
CUP promotes deadenylation and inhibits decapping of mRNA targets.CUP 促进 mRNA 靶标去腺苷酸化并抑制去帽。
Genes Dev. 2011 Sep 15;25(18):1955-67. doi: 10.1101/gad.17136311.
8
The DEAD-box protein Ded1 modulates translation by the formation and resolution of an eIF4F-mRNA complex.DEAD -box 蛋白 Ded1 通过形成和解离 eIF4F-mRNA 复合物来调节翻译。
Mol Cell. 2011 Sep 16;43(6):962-72. doi: 10.1016/j.molcel.2011.08.008.
9
Deciphering arginine methylation: Tudor tells the tale.解析精氨酸甲基化：Tudor 讲述了这个故事。
Nat Rev Mol Cell Biol. 2011 Sep 14;12(10):629-42. doi: 10.1038/nrm3185.
10
Depletion of eIF4G from yeast cells narrows the range of translational efficiencies genome-wide.从酵母细胞中耗尽 eIF4G 会缩小全基因组范围内翻译效率的范围。
BMC Genomics. 2011 Jan 26;12:68. doi: 10.1186/1471-2164-12-68.
Zotero 插件