Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, The University of Arizona, Tucson, Tucson, AZ, USA.
Cell Cycle. 2012 Jul 15;11(14):2594-9. doi: 10.4161/cc.20716.
A recent report demonstrates that a subset of RGG-motif proteins can bind translation initiation factor eIF4G and repress mRNA translation. This adds to the growing number of roles RGG-motif proteins play in modulating transcription, splicing, mRNA export and now translation. Herein, we review the nature and breadth of functions of RGG-motif proteins. In addition, the interaction of some RGG-motif proteins and other translation repressors with eIF4G highlights the role of eIF4G as a general modulator of mRNA function and not solely as a translation initiation factor.
最近的一份报告表明，RGG 基序蛋白的一个亚组可以结合翻译起始因子 eIF4G 并抑制 mRNA 翻译。这增加了 RGG 基序蛋白在调节转录、剪接、mRNA 输出以及现在的翻译中发挥作用的数量。在此，我们回顾了 RGG 基序蛋白的性质和广泛的功能。此外，一些 RGG 基序蛋白和其他翻译抑制剂与 eIF4G 的相互作用突出了 eIF4G 作为 mRNA 功能的一般调节剂的作用，而不仅仅是作为翻译起始因子。
