Watts P M, Taylor W A, Hughes R A
Department of Neurology, United Medical and Dental Schools, Guy's Hospital, London, United Kingdom.
Exp Neurol. 1989 Jan;103(1):101-4. doi: 10.1016/0014-4886(89)90191-x.
High dose methylprednisolone (50 mg kg-1, daily) was administered to Lewis rats with experimental allergic neuritis from onset of the disease. Disease severity was reduced and recovery was significantly more rapid than that in saline-injected controls. Histological examination showed reduction of endoneurial edema, cellular infiltration, and demyelination. The results provide experimental evidence supporting the trial of high dose steroids in human demyelinating polyradiculoneuropathy.
从疾病发作开始，就对患有实验性过敏性神经炎的Lewis大鼠给予高剂量甲基强的松龙（50毫克/千克，每日）。疾病严重程度降低，恢复速度明显快于注射生理盐水的对照组。组织学检查显示神经内膜水肿、细胞浸润和脱髓鞘减少。这些结果为高剂量类固醇用于人类脱髓鞘性多发性神经根神经病的试验提供了实验证据。
