Khalili Mohammad Ali, A Nottola Stefania, Shahedi Abbas, Macchiarelli Guido
Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, La Sapienza University, Rome, Italy.
Iran J Reprod Med. 2013 Jan;11(1):1-10.
The use of ovarian stimulation for infertility treatment is associated with side effects of ovarian hyperstimulation syndrome (OHSS) and potential cancer risk. This is also true in high risk women such as those polycystic with ovary (PCO) and polycystic ovarian syndrome (PCOS). In vitro maturation (IVM) of oocytes was primarily developed to make IVF safe for women with PCO and at high risk of OHSS. The application of IVM of oocytes to assist clinical infertility treatment remains poor because of the reduced developmental competence of oocytes after IVM, despite several decades of research. Reduced meiotic maturation and fertilization rates, as well as low blastocyst production reveal short-term developmental insufficiency of oocytes when compared with in vivo-matured counterparts. In this review, the structural role of human oocytes, revealed by different technical approaches, to the success of IVM technology is highlighted.
使用卵巢刺激进行不孕症治疗与卵巢过度刺激综合征（OHSS）的副作用及潜在癌症风险相关。对于多囊卵巢（PCO）和多囊卵巢综合征（PCOS）等高风险女性而言亦是如此。卵母细胞的体外成熟（IVM）最初是为了使IVF对患有PCO且有OHSS高风险的女性安全而开发的。尽管经过了几十年的研究，但由于IVM后卵母细胞发育能力降低，卵母细胞IVM在辅助临床不孕症治疗中的应用仍然很少。与体内成熟的卵母细胞相比，减数分裂成熟率和受精率降低以及囊胚生成率低表明卵母细胞存在短期发育不足。在这篇综述中，强调了通过不同技术方法揭示的人类卵母细胞对IVM技术成功的结构作用。
