Borna Sedigheh, Shariat Mamak, Fallahi Mohaddese, Janani Leila
Maternal-Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Maternal-Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran. ; Breast Feeding Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Reprod Med. 2013 Nov;11(11):861-8.
Our information regarding immunity to toxoplasmosis among reproductive age women is indeterminate and there is significant variation between reported results; it is necessary to perform a Meta-analysis study on subjects to obtain required findings and develop preventive measures accordingly.
Estimation level of immunity to toxoplasmosis in reproductive ages.
All published papers in main national and international databases were systematically searched for some specific keywords to find the related studies up to 2012. We selected only original articles that either reported percentage of positive anti toxoplasma IgG or total anti toxoplasma antibody by using ELISA or IFAT method (provided that the titer ≥1.20 is considered positive for IFAT) in childbearing age women.
Studies involved a total of 13480 participants. The maximum and minimum reported prevalence rates of anti-toxoplasma IgG antibody using IFTA serological method were 21.8% and 54%; and using ELISA serological method were 23% and 64%, respectively. The overall estimation for prevalence of anti-toxoplasma IgG antibody using IFTA serological method was 34.5% (95% CI: 28.5-40.5); and using ELISA method was 37.6% (95% CI: 30.4-44.9). The overall estimation for prevalence of anti-toxoplasma total antibody was 39.9% (95% CI: 26.1-53.7).
In Iran, screening of toxoplasma is not routinely performed yet, while the incidence of toxoplasmosis is too high to justify routine screening. Prenatal screening can help to identify mothers susceptible to infection. Screening for the presence of antibodies allows primary prevention of toxoplasmosis infection where eating habits and hygiene practices have clearly been identified as risk factors.
我们关于育龄妇女弓形虫免疫力的信息并不明确，报告结果之间存在显著差异；有必要对相关主题进行荟萃分析研究，以获得所需结果并据此制定预防措施。
评估育龄期妇女对弓形虫的免疫水平。
系统检索主要国家和国际数据库中截至2012年的所有已发表论文，使用特定关键词查找相关研究。我们仅选择那些通过酶联免疫吸附测定（ELISA）或间接荧光抗体试验（IFAT）方法报告抗弓形虫IgG阳性百分比或抗弓形虫总抗体的原始文章（前提是IFAT滴度≥1.20被视为阳性），研究对象为育龄妇女。
研究共涉及13480名参与者。使用IFTA血清学方法报告的抗弓形虫IgG抗体患病率最高和最低分别为21.8%和54%；使用ELISA血清学方法分别为23%和64%。使用IFTA血清学方法对抗弓形虫IgG抗体患病率的总体估计为34.5%（95%置信区间：28.5 - 40.5）；使用ELISA方法为37.6%（95%置信区间：30.4 - 44.9）。抗弓形虫总抗体患病率的总体估计为39.9%（95%置信区间：26.1 - 53.7）。
在伊朗，尚未常规进行弓形虫筛查，而弓形虫病的发病率过高，无法证明常规筛查的合理性。产前筛查有助于识别易感染的母亲。对抗体存在情况进行筛查可在明确饮食习惯和卫生习惯为危险因素的情况下，对弓形虫病感染进行一级预防。
