Rahmanian Vahid, Rahmanian Karamatollah, Jahromi Abdolreza Sotoodeh, Bokaie Saied
Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.
Epidemiology and Zoonosis Division, Department of Food Hygiene, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
J Family Med Prim Care. 2020 Aug 25;9(8):3848-3855. doi: 10.4103/jfmpc.jfmpc_753_20. eCollection 2020 Aug.
Toxoplasmosis is one of the neglected parasitic disease in humans and animals that produced via toxoplasma gondii. This study we implemented an umbrella review of all existing systematic reviews, meta-analyzing studies to apprise, and summarize seroprevalence of human toxoplasmosis in worldwide.
The search was carried out in databases including: Pub Med, Google Scholar, Science Direct, Scopus, Web of Science, Cochrane, and global health from their start dates until December 2018 in Persian and English language. A total of 21 systematics review and meta-analysis met the inclusion criteria of umbrella review. The Q test and the I statistic were used to evaluate heterogeneities. Quality assessment were performed and made use of the AMSTAR tool.
The estimated pooled seroprevalence of T. gondii infection in blood donors, Immunocompromised patients, childbearing age women, general population, newborns and children, pregnant women and overall was 33% (95% CI, 29.0-38.0%), 42.0% (95 CI, 34.0-49.0%), 32.0% (CI, 26.0-38.0%), 42.0% (CI, 38.0-45.0%), 4.0% (CI, 2.0-5.0%), 40.0% (CI,37.0-44.0%), and 36% (CI, 24.0-48.0%), respectively.
The results of our umbrella review show a higher seroprevalence of T. gondii infection in immunocompromised patients, general population, pregnant women, blood donors, childbearing age women, and newborn groups, respectively. Routine serologic screening test and health education by primary care physicians for Toxoplasmosis is recommended to be conducted in high-risk groups in the endemic region.
弓形虫病是由刚地弓形虫引起的一种在人类和动物中被忽视的寄生虫病。在本研究中，我们对所有现有的系统评价和荟萃分析研究进行了一项汇总分析，以评估并总结全球人类弓形虫病的血清阳性率。
检索数据库包括：PubMed、谷歌学术、科学Direct、Scopus、科学网、Cochrane以及全球卫生数据库，检索时间从各数据库起始日期至2018年12月，检索语言为波斯语和英语。共有21项系统评价和荟萃分析符合汇总分析的纳入标准。采用Q检验和I统计量评估异质性。使用AMSTAR工具进行质量评估。
估计献血者、免疫功能低下患者、育龄妇女、普通人群、新生儿和儿童、孕妇以及总体人群中弓形虫感染的合并血清阳性率分别为33%（95%CI，29.0 - 38.0%）、42.0%（95%CI，34.0 - 49.0%）、32.0%（CI，26.0 - 38.0%）、42.0%（CI，38.0 - 45.0%）、4.0%（CI，2.0 - 5.0%）、40.0%（CI，37.0 - 44.0%）和36%（CI，24.0 - 48.0%）。
我们的汇总分析结果显示，免疫功能低下患者、普通人群、孕妇、献血者、育龄妇女和新生儿组中弓形虫感染的血清阳性率较高。建议在流行地区的高危人群中由初级保健医生开展弓形虫病的常规血清学筛查试验和健康教育。
