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Mid-pregnancy maternal leptin levels, birthweight for gestational age and preterm delivery.孕中期母体内瘦素水平、胎儿生长发育与早产。
Clin Endocrinol (Oxf). 2013 Apr;78(4):607-13. doi: 10.1111/cen.12029.
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Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000.全球、区域和国家儿童死亡原因：2010 年更新的系统分析及 2000 年以来的时间趋势
Lancet. 2012 Jun 9;379(9832):2151-61. doi: 10.1016/S0140-6736(12)60560-1. Epub 2012 May 11.
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The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity.全球早产发生率：孕产妇死亡和发病的系统评价。
Bull World Health Organ. 2010 Jan;88(1):31-8. doi: 10.2471/BLT.08.062554. Epub 2009 Sep 25.
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Leptin--a tocolytic agent for the future?瘦素——一种未来的保胎药？
Med Hypotheses. 2010 Jan;74(1):81-2. doi: 10.1016/j.mehy.2009.07.039. Epub 2009 Aug 18.
5
Emerging tocolytics: challenges in designing and testing drugs to delay preterm delivery and prolong pregnancy.新型宫缩抑制剂：设计和测试延迟早产及延长孕期药物面临的挑战。
Expert Opin Emerg Drugs. 2008 Dec;13(4):695-707. doi: 10.1517/14728210802568764.
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The relationship between maternal plasma leptin levels and fetal growth restriction.母体血浆瘦素水平与胎儿生长受限之间的关系。
Endocr J. 2007 Dec;54(6):945-51. doi: 10.1507/endocrj.k06-225. Epub 2007 Nov 14.
7
Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia.正常妊娠、子痫前期及无子痫前期的胎儿生长受限孕妇血浆瘦素、胎盘瘦素mRNA和蛋白之间的关系。
Mol Hum Reprod. 2006 Sep;12(9):551-6. doi: 10.1093/molehr/gal064. Epub 2006 Jul 26.
8
The known and unknown of leptin in pregnancy.孕期瘦素的已知与未知
Am J Obstet Gynecol. 2006 Jun;194(6):1537-45. doi: 10.1016/j.ajog.2005.06.064. Epub 2006 Apr 21.
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Inhibitory effect of leptin on human uterine contractility in vitro.瘦素对人子宫体外收缩性的抑制作用。
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Maternal pre-pregnancy overweight and obesity and the risk of cesarean delivery in nulliparous women.未生育女性孕前超重和肥胖与剖宫产风险
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孕晚期母体血清瘦素水平与中度早产发生之间的关联。

The association between level of maternal serum leptin in the third trimester and the occurrence of moderate preterm labor.

作者信息

Fakor Fereshteh, Sharami Seyedeh Hajar, Milani Forozan, Mirblouk Fariba, Kazemi Sodabeh, Pourmarzi Davoud, Ebrahimi Hannan, Heirati Seyedeh Fatemeh Dalil

机构信息

Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran.

Reproductive Health Research Center, Department of Epidemiology, Guilan University of Medical Sciences, Rasht, Iran.

出版信息

J Turk Ger Gynecol Assoc. 2016 Dec 1;17(4):182-185. doi: 10.5152/jtgga.2016.16121. eCollection 2016.

DOI:10.5152/jtgga.2016.16121
PMID:27990085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5147755/
Abstract

OBJECTIVE

We aimed to investigate the relationship between the level of maternal serum leptin and the occurrence of moderate preterm labor.

MATERIAL AND METHODS

This was a case control study conducted on pregnant women referred to Al-Zahra Hospital in Rasht, north of Iran in 2013. Cases included 30 moderate preterm delivering women and 30 control pregnant women with the same gestational age. The maternal serum leptin was measured for each mother at the time of entering the study.

RESULTS

The mean serum leptin in the control group (56.66±34.18) was significantly higher than the preterm (33.65±16.70) group. There were no significant differences between the groups in terms of body mass index and age. Logistic regression revealed that age and body mass index did not have a significant relationship to moderate preterm birth. However, an increased leptin level as low as 1 microgram per liter was associated with the risk of moderate preterm birth incidence (OR: 0.973, CI: 0.948-0.997).

CONCLUSION

Higher levels of leptin in pregnant women are associated with a decreased risk of moderate preterm birth. Further investigations are recommended with a larger sample size.

摘要

目的

我们旨在研究孕妇血清瘦素水平与中度早产发生之间的关系。

材料与方法

这是一项于2013年对转诊至伊朗北部拉什特的阿尔-扎赫拉医院的孕妇进行的病例对照研究。病例包括30名中度早产的孕妇和30名孕周相同的对照孕妇。在进入研究时为每位母亲测量了孕妇血清瘦素。

结果

对照组的平均血清瘦素水平（56.66±34.18）显著高于早产组（33.65±16.70）。两组在体重指数和年龄方面无显著差异。逻辑回归显示年龄和体重指数与中度早产无显著关系。然而，瘦素水平每升高1微克/升就与中度早产发生率的风险相关（比值比：0.973，可信区间：0.948 - 0.997）。

结论

孕妇较高的瘦素水平与中度早产风险降低相关。建议进行更大样本量的进一步研究。