Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Evid Based Complement Alternat Med. 2013;2013:260235. doi: 10.1155/2013/260235. Epub 2013 Dec 29.
Atopic dermatitis (AD) is a common inflammatory skin disease with recurring episodes of itching and a chronic relapsing course. Current treatment options for AD include topical agents, such as topical corticosteroids and oral antiallergic drugs. Providing effective long-term treatment is sometimes difficult due to the chronic, relapsing nature of AD; therefore, there is a need to identify better therapeutic options with minimal side effects that are well tolerated over the variable course of the disease. Traditional herbal medicine, also known as Kampo medicine in Japan, has a long history and plays a role in the prevention and treatment of various diseases, including AD. Some Kampo medicines are useful for treating inflammatory skin diseases, and there has been increased interest in using Kampo medicine to develop new therapeutic agents for AD. Standard Kampo formulas for AD are effective in removing the symptoms of "Netsu Sho," "Ketsu-Kyo," "Ki-Kyo," and "O-Ketsu." This paper discusses the efficacy of Kampo medicines in treating AD. Knowledge of the mechanisms of action of Kampo medicines will result in greater choices of pharmacotherapeutic agents for AD.
特应性皮炎（AD）是一种常见的炎症性皮肤病，具有反复发作的瘙痒和慢性复发性病程。AD 的当前治疗选择包括局部制剂，如局部皮质类固醇和口服抗过敏药物。由于 AD 的慢性、复发性性质，提供有效的长期治疗有时很困难；因此，需要确定具有最小副作用的更好治疗选择，这些选择在疾病的不同病程中都能很好地耐受。传统草药医学，在日本也称为汉方药，具有悠久的历史，在预防和治疗各种疾病方面发挥着作用，包括 AD。一些汉方药对治疗炎症性皮肤病有用，并且人们越来越有兴趣使用汉方药来开发 AD 的新治疗剂。用于 AD 的标准汉方制剂对消除“热湿”、“血燥”、“气燥”和“火燥”的症状有效。本文讨论了汉方药治疗 AD 的疗效。对汉方药作用机制的了解将为 AD 的药物治疗提供更多选择。
