Soskić Sanja, Stokić Edita, Isenović Esma R
Institute of nuclear sciences 'Vinca', Laboratory for Radiobiology and Molecular Genetics, University of Belgrade , Belgrade , Serbia.
Curr Med Res Opin. 2014 Jun;30(6):1197-9. doi: 10.1185/03007995.2014.900004. Epub 2014 Mar 18.
Currently, vitamin D deficiency and obesity are pandemic diseases and they are associated with cardiovascular (CV) disease, metabolic syndrome and type 2 diabetes mellitus (T2DM) and other diseases. Concentrations of 25-hydroxyvitamin D (25(OH)D) (25D) are considered as the best indicator of total body vitamin D stores. An association between reduced circulating 25D concentrations and obesity is well known, but the mechanisms are not totally clear. The role of vitamin D supplementation is still uncertain and prospective interventions will establish its influence, if any, in the treatment of obesity. Vitamin D deficiency is associated with the presence of a cardiometabolic risk profile in the obese. Future trials may establish a role for Vitamin D supplementation in individuals at increased CV risk.
目前，维生素D缺乏和肥胖是全球性疾病，它们与心血管（CV）疾病、代谢综合征和2型糖尿病（T2DM）以及其他疾病相关。25-羟基维生素D（25(OH)D）（25D）的浓度被认为是全身维生素D储备的最佳指标。循环中25D浓度降低与肥胖之间的关联是众所周知的，但机制尚不完全清楚。维生素D补充剂的作用仍不确定，前瞻性干预将确定其在肥胖治疗中的影响（如果有）。维生素D缺乏与肥胖者存在心脏代谢风险特征有关。未来的试验可能会确定维生素D补充剂在心血管风险增加个体中的作用。
