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[用灭活非浓缩狂犬病疫苗免疫的CBA品系小鼠脾细胞保护作用的体内研究]

[In vivo study of the protective action of the splenocytes from CBA strain mice immunized with an inactivated nonconcentrated rabies vaccine].

作者信息

Gribencha S V, Kiseleva A S, Barinskiĭ I F

出版信息

Vopr Virusol. 1986 Nov-Dec;31(6):691-5.

PMID:3493590
Abstract

An inactivated unconcentrated rabies vaccine was demonstrated to induce the production of T-killers which in adoptive transfer protect 38-43% of recipients challenged intramuscularly with street rabies virus. The production of T-killers depends on the dose and schedule of the antigen inoculation. T-killers in vivo were strictly specific and manifested their protective effect only in syngeneic but not in allogeneic system.

摘要

一种灭活的未浓缩狂犬病疫苗被证明可诱导产生杀伤性T细胞,在过继转移中,这些杀伤性T细胞能保护38% - 43%经肌肉注射街狂犬病毒攻击的受体。杀伤性T细胞的产生取决于抗原接种的剂量和程序。体内的杀伤性T细胞具有严格的特异性,仅在同基因系统而非异基因系统中表现出保护作用。

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