Gribencha S V, Barinskiĭ I F
Vopr Virusol. 1989 May-Jun;34(3):325-30.
Experiments in CBA, mice immunized with inactivated unconcentrated cultural rabies vaccine (CRV) demonstrated that a clone of T-effectors of memory was formed within 30-37 days after primary immunization which reacted by the secondary type in response to inoculation of subthreshold doses of the rabies antigen. This clone of immunological memory seems to remain in the quiescent state for very long periods (the observation period 406 days). The immune splenocytes from the donors which had been given subthreshold doses of the antigen at intervals of 60, 103, 180 and 406 days, protected 2-4 times more animals than those after primary immunization with a threshold dose of the antigen. A continuous state of cell-mediated immunity--T-effectors processing the protective properties in vivo--may be maintained by repeated threshold doses of antigen given at 7-day intervals. The observed patterns of the induction of T-effectors possessing protective properties in vivo allowed some principles for construction of the optimal schedule of rabies vaccination to be formulated.
在CBA小鼠中进行的实验表明，用未浓缩的灭活狂犬病培养疫苗（CRV）免疫的小鼠在初次免疫后30 - 37天内形成了记忆性T效应细胞克隆，该克隆对低于阈值剂量的狂犬病抗原接种产生二次反应。这种免疫记忆克隆似乎会在很长一段时间内保持静止状态（观察期为406天）。在间隔60、103、180和406天给予低于阈值剂量抗原的供体的免疫脾细胞，保护的动物数量比用阈值剂量抗原进行初次免疫后的多2 - 4倍。通过每隔7天给予重复的阈值剂量抗原，可以维持细胞介导免疫的持续状态——即体内具有保护特性的T效应细胞的状态。体内诱导具有保护特性的T效应细胞的观察模式为制定狂犬病疫苗接种的最佳方案提供了一些原则。
