莳萝叶水提取物对戊四氮诱导小鼠癫痫发作的影响。
Effects of the Aqueous Extract of Anethum graveolens Leaves on Seizure Induced by Pentylenetetrazole in Mice.
作者信息
Arash Akaberi, Mohammad Mohammad-Zadeh, Jamal Mirmoosavi Seyed, Mohammad Tazari Ali, Azam Abarashi
机构信息
Addiction and Behavioral Sciences Research Center, North Khorasan University of Medical Sciences, PO Box 9414953535, Bojnurd, Iran.
Cellular and Molecular Research Center, Department of Physiology & Pharmacology, School of Medicine, Sabzevar University of Medical Sciences, PO Box 9613596135, Sabzevar, Iran.
出版信息
Malays J Med Sci. 2013 Oct;20(5):23-30.
BACKGROUND
In this study, the aqueous extract of Anethum graveolens (dill) leaves was studied for its effects on treating convulsions and epilepsy, by using a pentylenetetrazole (PTZ) kindling model. The evaluated plant has a traditional medical reputation for profound anticonvulsant activities, additionally, dill has been claimed to exhibit anti-inflammatory and analgesic properties.
METHODS
For the PTZ kindling induction, mice were given a dose of PTZ (37 mg/kg, intraperitoneally) every other day, and seizure stages were precisely recorded. During and after kindling, the effects of the non-toxic doses of the aqueous extracts (100, 250, and 400 mg/kg) on seizure latency in stage 2 (S2L), seizure latency in stage 4 (S4L), and seizure duration in stage 5 (S5D) were measured.
RESULTS
The aqueous extract of dill leaves had a noticeable anticonvulsant effect. The 400 mg/kg dose of the extract sample decreased with S5D (P < 0.05), and increased with S2L and S4L significantly (P < 0.05 and P < 0.01, respectively).
CONCLUSION
The obtained data shows that the aqueous extract possesses anticonvulsant activity against seizure induced by PTZ. The presence of anticonvulsant compounds in this medicinal herb suggests further activity and guided fractionation studies in order to introduce this plant as a valuable source of anticonvulsant agents.
背景
在本研究中，通过使用戊四氮（PTZ）点燃模型，研究了莳萝叶水提取物对惊厥和癫痫的治疗作用。该受试植物在传统医学中以具有显著的抗惊厥活性而闻名，此外，莳萝还被宣称具有抗炎和镇痛特性。
方法
为诱导PTZ点燃，每隔一天给小鼠腹腔注射一剂PTZ（37mg/kg），并精确记录癫痫发作阶段。在点燃过程中和点燃后，测量无毒剂量的水提取物（100、250和400mg/kg）对2期癫痫发作潜伏期（S2L）、4期癫痫发作潜伏期（S4L）和5期癫痫发作持续时间（S5D）的影响。
结果
莳萝叶水提取物具有显著的抗惊厥作用。提取物样品400mg/kg剂量可使S5D降低（P<0.05），并使S2L和S4L显著增加（分别为P<0.05和P<0.01）。
结论
所得数据表明，该水提取物对PTZ诱导的癫痫发作具有抗惊厥活性。这种药用植物中抗惊厥化合物的存在表明需要进一步开展活性和导向分级研究，以便将这种植物作为抗惊厥药物的宝贵来源。
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