Cekmez Y, Ozkaya E, Öcal F D, Süer N, Küçüközkan T
Department of Obstrectic and Gynecology, Sami Ulus Medical and Research Hospital, 34090, Ankara, Turkey,
Ir J Med Sci. 2015 Jun;184(2):285-9. doi: 10.1007/s11845-014-1101-8. Epub 2014 Mar 19.
This study was performed to investigate the role of first-hour 50-g oral glucose challenge test (GCT) parameters in predicting the risk of delivering a small-for-gestational-age infant and to determine the accuracy of estimated fetal weight.
We screened 2,643 pregnant women >20 years of age and excluded 552 patients according to exclusion criteria. Newborns were assigned to three groups as SGA(n:100), AGA(n:100), and LGA(n:100) according to birth weight. All mothers received 50-g GCT in their 24-28th weeks of gestation. We examined the relationship between birthweight and test results.
First-hour serum glucose level after the test significantly predicted babies with small for gestational age. Optimal cutoff value was obtained at a level of 74.5 mg/dl with 67% sensitivity and 55% specificity. The estimated fetal weight of Hadlock 5 formula was strongly correlated with the birth weight (Pearson r = 0.89).
Our study revealed that 50-g oral glucose challenge test may predict small-for-gestational-age cases with 67% sensitivity, and our data revealed that there is a significant correlation between estimated fetal weight of Hadlock 5 formula and the birth weight.
本研究旨在探讨孕早期50克口服葡萄糖耐量试验（GCT）参数在预测小于胎龄儿出生风险中的作用，并确定胎儿体重估计值的准确性。
我们对2643名年龄大于20岁的孕妇进行了筛查，并根据排除标准排除了552例患者。根据出生体重将新生儿分为三组：小于胎龄儿组（n = 100）、适于胎龄儿组（n = 100）和大于胎龄儿组（n = 100）。所有母亲在妊娠24 - 28周时接受50克GCT。我们研究了出生体重与测试结果之间的关系。
测试后第1小时血清葡萄糖水平显著预测了小于胎龄儿。最佳截断值为74.5毫克/分升，敏感性为67%，特异性为55%。Hadlock 5公式的胎儿体重估计值与出生体重密切相关（Pearson相关系数r = 0.89）。
我们的研究表明，50克口服葡萄糖耐量试验可预测小于胎龄儿病例，敏感性为67%，我们的数据表明，Hadlock 5公式的胎儿体重估计值与出生体重之间存在显著相关性。
