Shen Ben, Liang Quiyan, Gao Weiqi, You Chu, Hong Mengqi, Ma Qing
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2013 Dec;30(6):1186-90.
The conductivity and permittivity of blood in mice were measured by the AC electrical impedance method at frequency range of 0.1-100MHz, and then the changes of the Cole-Cole parameters of dielectric spectra of blood from phenylhydrazine-induced anemia mice were observed by numerical calculation and curve fitting residual analysis of the Cole-Cole equation. The results showed that hematocrit (Hct) of the mice with phenylhydrazine injection was significantly reduced; the permittivity(epsilon) spectroscopy of blood moved to the low insulating region and its permittivity decreased; conductivity (kappa) spectrum curve of blood moved to the high conductivity zone and conductivity increased; the 2nd characteristic frequency was lower than that in the normal group. There was phenylhydrazine dose dependent in the changes of the Cole-Cole parameters of dielectric spectra of blood.
采用交流电阻抗法在0.1 - 100MHz频率范围内测量小鼠血液的电导率和介电常数,然后通过对Cole - Cole方程进行数值计算和曲线拟合残差分析,观察苯肼诱导的贫血小鼠血液介电谱的Cole - Cole参数变化。结果显示,注射苯肼的小鼠血细胞比容(Hct)显著降低;血液的介电常数(ε)谱向低绝缘区域移动且介电常数降低;血液的电导率(κ)谱曲线向高电导率区域移动且电导率增加;第二特征频率低于正常组。血液介电谱的Cole - Cole参数变化存在苯肼剂量依赖性。