Turoń-Skrzypińska Agnieszka, Dutkiewicz Grażyna, Marchelek-Myśliwiec Małgorzata, Rył Aleksandra, Dziedziejko Violetta, Safranow Krzysztof, Ciechanowski Kazimierz, Rotter Iwona
Department of Medical Rehabilitation and Clinical Rehabilitation, Pomeranian Medical University, Szczecin 71-210, Poland.
Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin 70-111, Poland.
Risk Manag Healthc Policy. 2020 Sep 7;13:1467-1475. doi: 10.2147/RMHP.S255780. eCollection 2020.
Chronic kidney disease and renal replacement therapy are associated with reduced motor activity, which may result in the presence of mineral bone disorders and an increase in inflammation markers. The aim of the study was to assess the relationship between the performance of daily physical activity, expressed in the number of steps performed by patients undergoing hemodialysis and the concentration of selected biochemical parameters (SCL, IL-6).
The study group (B) involved 33 patients aged 59.8 ± 9.8 years from the dialysis station at the Department of Nephrology, Transplantology and Internal Medicine PUM. In group B, interventions considering an increase in physical activity expressed in the number of steps were introduced. Group C consisted of 30 people aged 54.9 (9.37), with GFR over 60 mL/min/1.73m. Physical activity was measured with pedometers. Anthropometric and biochemical parameters were assessed at baseline, after the third and sixth month of the study. Descriptive statistics, intergroup comparisons using Mann-Whitney U test and Spearman correlation analysis were performed. The level of significance was set at p≤0.005.
A relationship between IL-6 concentration and the number of steps in group B after three months of intervention was demonstrated. In group C, the concentration of SCL and IL-6 decreased with the increase in the number of steps taken. Only in group C the waist circumference decreased with the increase of the number of steps performed.
Patients receiving renal replacement therapy by hemodialysis showed significantly lower physical activity compared to people without kidney disease. Performing bigger number of steps can lower interleukin 6 levels in hemodialysis patients.
慢性肾脏病和肾脏替代治疗与运动活动减少有关，这可能导致矿物质骨病的出现以及炎症标志物增加。本研究的目的是评估以接受血液透析患者的步数表示的日常身体活动表现与选定生化参数（SCL、IL-6）浓度之间的关系。
研究组（B组）包括来自波美拉尼亚医科大学肾脏病、移植学和内科血液透析站的33名年龄为59.8±9.8岁的患者。在B组中，引入了以步数增加表示的身体活动增加的干预措施。C组由30名年龄为54.9（9.37）岁、肾小球滤过率超过60 mL/min/1.73m²的人组成。使用计步器测量身体活动。在研究的基线、第三个月和第六个月后评估人体测量和生化参数。进行描述性统计、使用曼-惠特尼U检验的组间比较和斯皮尔曼相关性分析。显著性水平设定为p≤0.005。
干预三个月后，B组中IL-6浓度与步数之间存在关系。在C组中，SCL和IL-6的浓度随着步数的增加而降低。只有在C组中，腰围随着步数增加而减小。
与无肾脏疾病的人相比，接受血液透析肾脏替代治疗的患者身体活动明显较低。进行更多步数可降低血液透析患者的白细胞介素6水平。
