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人源抗菌肽LL-37耐药及耐甲氧西林金黄色葡萄球菌USA600（ST45）菌株中达托霉素最低抑菌浓度增加与医院环境中死亡率升高相关。

Human cathelicidin LL-37 resistance and increased daptomycin MIC in methicillin-resistant Staphylococcus aureus strain USA600 (ST45) are associated with increased mortality in a hospital setting.

作者信息

Sakoulas George, Guram Kripa, Reyes Katherine, Nizet Victor, Zervos Marcus

机构信息

University of California San Diego School of Medicine, La Jolla, California, USA

University of California San Diego School of Medicine, La Jolla, California, USA.

出版信息

J Clin Microbiol. 2014 Jun;52(6):2172-4. doi: 10.1128/JCM.00189-14. Epub 2014 Mar 19.

DOI:10.1128/JCM.00189-14
PMID:24648548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4042812/
Abstract

Bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) USA600 has been associated with increased patient mortality. We found that USA600 MRSA exhibited significantly increased resistance to human cathelicidin LL-37 killing and daptomycin MIC creep compared to non-USA600 MRSA. Virulent health care-associated MRSA strains may coevolve innate host defense peptide and antibiotic resistances.

摘要

耐甲氧西林金黄色葡萄球菌（MRSA）USA600引起的菌血症与患者死亡率增加有关。我们发现，与非USA600 MRSA相比，USA600 MRSA对人cathelicidin LL-37杀伤的抗性显著增加，对达托霉素的最低抑菌浓度（MIC）漂移也更明显。具有强毒力的医疗保健相关MRSA菌株可能会共同进化出针对宿主天然防御肽的抗性和抗生素抗性。

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本文引用的文献

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Emergence of daptomycin resistance in daptomycin-naïve rabbits with methicillin-resistant Staphylococcus aureus prosthetic joint infection is associated with resistance to host defense cationic peptides and mprF polymorphisms.耐万古霉素金黄色葡萄球菌人工关节感染的达托霉素初治兔出现达托霉素耐药与宿主防御阳离子肽耐药和 mprF 多态性有关。
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Molecular epidemiology of community-associated methicillin-resistant Staphylococcus aureus in the genomic era: a cross-sectional study.基因组时代社区获得性耐甲氧西林金黄色葡萄球菌的分子流行病学：一项横断面研究。
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Readmission following hospitalization for pneumonia: the impact of pneumonia type and its implication for hospitals.肺炎住院后再入院：肺炎类型的影响及其对医院的意义。
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Is it time to replace vancomycin in the treatment of methicillin-resistant Staphylococcus aureus infections?是否到了在耐甲氧西林金黄色葡萄球菌感染的治疗中替换万古霉素的时候了？
Clin Infect Dis. 2013 Jun;56(12):1779-88. doi: 10.1093/cid/cit178. Epub 2013 Mar 19.
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