Castaldo L, Andreozzi G, Antonucci R, Gargiulo G
Dipartimento di Strutture, funzioni e tecnologie biologiche, Università degli Studi, Napoli, Italy.
Basic Appl Histochem. 1988;32(4):511-21.
The distribution of chromogranin A and neuron specific enolase (NSE) in the neuroendocrine gut system and the morphology and distribution of cells containing gastrin, somatostatin, neurotensin and VIP in the gastroenteropacreatic (GEP) apparatus of Erinaceus europaeus were investigated by immunohistochemical methods. Chromogranin A and somatostatin immunoreactive cells were present throughout the gastrointestinal mucosa, with the exception of the oesophagus and in the pancreas. Gastrin cells were peculiar of the pyloric glands and duodenal mucosa and neurotensin cells of the small intestine. No VIP immunoreactive endocrine cells were noticed in the GEP system. VIP and NSE immunoreactivities were detected both in nerve cell bodies and terminals of the wall of the GEP apparatus. NSE immunoreactivity was found in the endocrine cells of the fundic and pyloric mucosa.
采用免疫组织化学方法研究了欧洲刺猬胃肠胰（GEP）器官中嗜铬粒蛋白A和神经元特异性烯醇化酶（NSE）在神经内分泌肠道系统中的分布，以及含胃泌素、生长抑素、神经降压素和血管活性肠肽（VIP）的细胞的形态和分布。嗜铬粒蛋白A和生长抑素免疫反应性细胞存在于整个胃肠道黏膜中，但食管和胰腺除外。胃泌素细胞见于幽门腺和十二指肠黏膜，神经降压素细胞见于小肠。在GEP系统中未发现VIP免疫反应性内分泌细胞。在GEP器官壁的神经细胞体和终末中均检测到VIP和NSE免疫反应性。在胃底和幽门黏膜的内分泌细胞中发现了NSE免疫反应性。
