Ilic Antonela, Panagiotoglou Dimitra, Galanis Eleni, Taylor Marsha, Butt Zahid A, Majowicz Shannon E
School of Public Health Sciences, University of Waterloo, Waterloo, Canada.
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada.
Epidemiol Infect. 2024 Dec 18;153:e7. doi: 10.1017/S0950268824001821.
This study investigated cases of pregnancy-related listeriosis in British Columbia (BC), Canada, from 2005 to 2014. We described all diagnosed cases in pregnant women ( = 15) and neonates ( = 7), estimated the excess healthcare costs associated with listeriosis, and calculated the fraction of stillbirths attributable to listeriosis, and mask cell sizes 1-5 due to data requirements. Pregnant women had a median gestational age of 31 weeks at listeriosis onset (range: 20-39) and on average delivered at a median of 37 weeks gestation (range: 20-40). Neonates experienced complications but no fatalities. Stillbirths occurred in 1-5 of 15 pregnant women with listeriosis, and very few (0.05-0.24%) of the 2,088 stillbirths in BC in the 10 years were attributed to listeriosis (exact numbers masked). Pregnant women and neonates with listeriosis had significantly more hospital visits, days in the hospital and physician visits than those without listeriosis. Pregnant women with listeriosis had 2.59 times higher mean total healthcare costs during their pregnancy, and neonates with listeriosis had 9.85 times higher mean total healthcare costs during their neonatal period, adjusting for various factors. Despite small case numbers and no reported deaths, these results highlight the substantial additional health service use and costs associated with individual cases of pregnancy-related listeriosis in BC.
本研究调查了2005年至2014年加拿大不列颠哥伦比亚省（BC）与妊娠相关的李斯特菌病病例。我们描述了所有确诊的孕妇病例（n = 15）和新生儿病例（n = 7），估计了与李斯特菌病相关的额外医疗费用，计算了可归因于李斯特菌病的死产比例，并因数据要求掩盖了1 - 5个单元格大小。孕妇李斯特菌病发病时的孕周中位数为31周（范围：20 - 39周），平均分娩孕周中位数为37周（范围：20 - 40周）。新生儿出现了并发症，但无死亡病例。15例患李斯特菌病的孕妇中有1 - 5例发生死产，BC省10年中2088例死产中极少部分（0.05 - 0.24%）归因于李斯特菌病（确切数字被掩盖）。患李斯特菌病的孕妇和新生儿比未患该病的孕妇和新生儿的医院就诊次数、住院天数和看医生次数显著更多。在调整各种因素后，患李斯特菌病的孕妇孕期平均总医疗费用高出2.59倍，患李斯特菌病的新生儿新生儿期平均总医疗费用高出9.85倍。尽管病例数较少且无死亡报告，但这些结果凸显了BC省与妊娠相关的李斯特菌病个别病例相关的大量额外医疗服务使用和费用。
