Turner Grant A, Sutton Stephanie, Sharma Ashish
Mr. Turner is a third year medical student, Ms. Sutton is a fourth year medical student, and Dr. Sharma is Associate Professor of Consult/Liaison Psychiatry; all from University of Nebraska Medical Center, Psychiatry Department, Omaha, Nebraska.
Innov Clin Neurosci. 2014 Jan;11(1-2):29-31.
We present a case of a 21-year-old woman with excoriation disorder that was resistant to currently reported treatment options. Severe lesions were present on multiple sites of her body. The skin picking appeared to be associated with anxiety surrounding her current medical stay and medical condition. The addition of aripiprazole to the venlafaxine she was already taking resulted in resolution of her unconscious picking. This medication combination may be considered by clinicians in the future for treatment-resistant excoriation disorder as its side effect profile is favorable for patients who have failed first-line treatment options. Large-scale studies investigating the use of second generation antipsychotics combined with selective serotonin reuptake inhibitors/serotonin norepinephrine reuptake inhibitors for the treatment of excoriation disorder is recommended.
我们报告了一例21岁患有搔抓障碍的女性病例，该病例对目前报道的治疗方案均有抵抗。她身体的多个部位出现了严重皮损。皮肤搔抓似乎与她目前住院期间及病情相关的焦虑情绪有关。在她已服用的文拉法辛基础上加用阿立哌唑后，她的无意识搔抓行为得到缓解。由于这种药物组合的副作用对一线治疗方案失败的患者较为有利，临床医生未来在治疗难治性搔抓障碍时可考虑使用。建议开展大规模研究，调查第二代抗精神病药物联合选择性5-羟色胺再摄取抑制剂/5-羟色胺去甲肾上腺素再摄取抑制剂用于治疗搔抓障碍的情况。
