肉毒梭菌中硫胺素抗维生素的生物合成。
Biosynthesis of a thiamin antivitamin in Clostridium botulinum.
机构信息
Department of Chemistry, Texas A&M University , College Station, Texas 77842, United States.
出版信息
Biochemistry. 2014 Apr 15;53(14):2215-7. doi: 10.1021/bi500281a. Epub 2014 Apr 1.
Abstract
Bacimethrin-derived 2'-methoxythiamin pyrophosphate inhibits microbial growth by disrupting metabolic pathways dependent on thiamin-utilizing enzymes. This study describes the discovery of the bacimethrin biosynthetic gene cluster of Clostridium botulinum A ATCC 19397 and in vitro reconstitution of bacimethrin biosynthesis from cytidine 5'-monophosphate.
摘要
双甲脒衍生的 2'-甲氧基噻嘧啶焦磷酸通过破坏依赖于硫胺素利用酶的代谢途径来抑制微生物的生长。本研究描述了肉毒梭菌 A ATCC 19397 的双甲脒生物合成基因簇的发现，以及从胞苷 5'-单磷酸体外重新合成双甲脒生物合成。
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