来自龙葵的具有细胞毒性的新倍半萜衍生物。
New sesquiterpenoid derivatives from Solanum septemlobum with cytotoxicities.
作者信息
Zhang Lei, Lin Hai-Qing, Li Gui-Sheng, Yue Xi-Dian, Dai Sheng-Jun
机构信息
a School of Pharmaceutical Science, Yantai University , Yantai 264005 , P.R. China.
出版信息
Nat Prod Res. 2015;29(20):1889-93. doi: 10.1080/14786419.2015.1010164. Epub 2015 Feb 13.
Two new sesquiterpenoid derivatives, attributable to eudesmane-type (1-2, named septemlobin D and 11,12-O-isopropylidenesolajiangxin F), were isolated from the whole plant of Solanum septemlobum. Their structures were elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D and 2D-NMR ((1)H-(1)H COSY, HMQC, HMBC and ROESY). In vitro, two sesquiterpenoid derivatives were found to show significant cytotoxicity against three cancer cell lines (P-388, HONE-1 and HT-29), and gave IC50 values in the range of 3.0-7.3 μM.
从龙葵全草中分离出两种新的倍半萜衍生物，属于桉叶烷型（1-2，分别命名为七叶皂苷D和11,12-O-异丙叉基异刺江蓠素F）。它们的结构通过综合光谱技术得以阐明，主要是高分辨快原子轰击质谱、一维和二维核磁共振（（1）H-（1）H 相关谱、异核多量子相干、异核多键相关和旋转异构体相关谱）。在体外，发现这两种倍半萜衍生物对三种癌细胞系（P-388、HONE-1和HT-29）显示出显著的细胞毒性，半数抑制浓度值在3.0-7.3 μM范围内。
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