From the Neuroscience Research Institute (Y.D.S., Z.H.C., E.J.C., Jeong-Hee Kim, H.K.K., S.Y.L., C.W.P., Y.B.K.) and Department of Psychiatry, Gil Medical Center (Jong-Hoon Kim), Gachon University, 1198 Kuwol-Dong, Namdong-Gu, Incheon 405-760, South Korea; and Department of Pathology, Seoul National University, Seoul, South Korea (J.G.C.).
Radiology. 2014 Aug;272(2):541-8. doi: 10.1148/radiol.14131547. Epub 2014 Mar 21.
To measure the activity of individual raphe nuclei with fluorine 18 fluorodeoxyglucose (FDG) and carbon 11 ((11)C) 3-amino-4-(2-dimethylaminomethylphenylthio) benzonitrile (DASB) imaging using a brain positron emission tomography(PET)/magnetic resonance (MR) imaging fusion system.
The study was approved by the Institutional Review Board of Gil Medical Center, and all volunteers provided written informed consent. FDG PET, (11)C-DASB PET, and T2*-weighted MR images from seven healthy volunteers were acquired by using a PET/MR imaging fusion system. The standard uptake value ratio (SUVR) of FDG (FDG-SUVR) and nondisplaceable binding potential (BPnd) of (11)C-DASB (DASB-BPnd) were determined for each raphe nucleus. A Pearson correlation analysis was performed to show the correlation between FDG-SUVR and DASB-BPnd for the raphe nuclei.
Each raphe nucleus could be distinguished in both FDG (identifiability ratio, 0.86; κ = 0.77) and (11)C-DASB (identifiability ratio, 0.89; κ = 0.72) images. The mean values of DASB-BPnd for each raphe nucleus from dorsal to caudal direction were 6.08 (raphe nucleus 1), 5.93 (raphe nucleus 2), 3.86 (raphe nucleus 3), 3.18 (raphe nucleus 4), and 2.74 (raphe nucleus 5); the mean FDG-SUVR values were 1.00 (raphe nucleus 1), 1.00 (raphe nucleus 2), 0.87 (raphe nucleus 3), 0.94 (raphe nucleus 4), and 0.90 (raphe nucleus 5). FDG-SUVR and DASB-BPnd for the raphe nuclei were significantly correlated (r = 0.506, P = .002).
Serotonergic activity, both glucose metabolism and transporter binding potential of raphe nuclei, were measured with a brain-dedicated PET/MR imaging system and showed a significant correlation.
使用氟 18 氟脱氧葡萄糖（FDG）和碳 11（11）C 3-氨基-4-（2-二甲氨基甲基苯基硫代）苯腈（DASB）成像，通过脑正电子发射断层扫描（PET）/磁共振（MR）成像融合系统测量单个中缝核的活性。
该研究得到了 Gil 医疗中心机构审查委员会的批准，所有志愿者均提供了书面知情同意书。通过 PET/MR 成像融合系统采集了 7 名健康志愿者的 FDG PET、11C-DASB PET 和 T2*-加权 MR 图像。确定了每个中缝核的 FDG 的标准化摄取值比（FDG-SUVR）和 11C-DASB 的不可置换结合潜能（DASB-BPnd）。进行了 Pearson 相关性分析，以显示中缝核的 FDG-SUVR 与 DASB-BPnd 之间的相关性。
在 FDG（可识别率，0.86；κ=0.77）和 11C-DASB（可识别率，0.89；κ=0.72）图像中均可区分每个中缝核。从背侧向尾侧方向的每个中缝核的 DASB-BPnd 平均值分别为 6.08（中缝核 1）、5.93（中缝核 2）、3.86（中缝核 3）、3.18（中缝核 4）和 2.74（中缝核 5）；FDG-SUVR 值的平均值分别为 1.00（中缝核 1）、1.00（中缝核 2）、0.87（中缝核 3）、0.94（中缝核 4）和 0.90（中缝核 5）。中缝核的 FDG-SUVR 和 DASB-BPnd 显著相关（r=0.506，P=0.002）。
使用专门用于脑的 PET/MR 成像系统测量了 5-羟色胺能活性，包括中缝核的葡萄糖代谢和转运体结合潜能，并显示出显著相关性。
