College of Medical Laboratory, Dalian Medical University, Dalian 116044, China.
J Transl Med. 2014 Mar 22;12:78. doi: 10.1186/1479-5876-12-78.
The clinical prediction of survival is among the most challenging tasks because it refers to the process whereby the medical team assimilates clinical data using subjective methods. The purpose of this prospective observational study was to develop a model for evaluating survival time using objective laboratory parameters.
Albumin (ALB), creatinine (CRE), C-reactive protein (CRP) and the neutrophilic leukocyte count (NEU) were measured using automated analysers. A total of 177 subjects with any one positive item of 4 items were included in the study. Age on the observation date and date of death were recorded.
ALB, CRE, CRP and the NEU were all significant predictors of survival time (p < 0.05). The median survival time of patients with anyone of the 4 items positive would be over 1 year; if any 2 items were positive, the median survival time was approximately 1 year; if any 3 items were positive, the median survival time was approximately 4 months and if 4 items were positive, the median survival time was approximately 20 days.
This study suggests that a model using ALB, CRE, CRP and the NEU is potentially useful in the objective evaluation of survival time in terminally ill patients.
临床预测生存是最具挑战性的任务之一，因为它涉及到医疗团队使用主观方法综合临床数据的过程。本前瞻性观察研究的目的是开发一种使用客观实验室参数评估生存时间的模型。
使用自动分析仪测量白蛋白（ALB）、肌酐（CRE）、C 反应蛋白（CRP）和中性粒细胞计数（NEU）。共纳入 177 例 4 项中有任何一项阳性的患者。记录观察日期的年龄和死亡日期。
ALB、CRE、CRP 和 NEU 均是生存时间的显著预测因子（p < 0.05）。任何 4 项中有 1 项阳性的患者中位生存时间超过 1 年；如果有 2 项阳性，中位生存时间约为 1 年；如果有 3 项阳性，中位生存时间约为 4 个月；如果 4 项均阳性，中位生存时间约为 20 天。
本研究表明，使用 ALB、CRE、CRP 和 NEU 的模型可能有助于客观评估终末期患者的生存时间。
