老年亚临床抑郁患者前扣带回皮质局部活动和功能连接的改变。
Altered local activity and functional connectivity of the anterior cingulate cortex in elderly individuals with subthreshold depression.
机构信息
Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Research Center of Emotion Regulation, Beijing Normal University, Beijing 100875, China.
Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; School of Nursing, Peking Union Medical College, Beijing 100144, China.
出版信息
Psychiatry Res. 2014 Apr 30;222(1-2):29-36. doi: 10.1016/j.pscychresns.2014.02.013. Epub 2014 Mar 4.
The anterior cingulate cortex (ACC) is recognized as a key structure in the pathogenesis of depression. This study aimed to investigate the resting-state regional activity and functional connectivity of the ACC in a community sample of elderly individuals with subthreshold depression (StD). We employed resting-state functional magnetic resonance imaging to acquire data from 19 elderly subjects with StD and 18 normal controls. We used a regional amplitude of low-frequency fluctuation (ALFF) analysis and a correlation-based functional connectivity (FC) approach to explore changes in local activity and remote connectivity of the ACC in StD. Compared to controls, the StD group demonstrated increased ALFF in the anterior portion of the dorsal ACC (adACC). The adACC also displayed increased FC with the dorsolateral prefrontal cortex and supplementary motor area and decreased FC with several subcortical regions. The FC levels of the adACC displayed a trending correlation with self-reported depressive symptoms. This study is the first to reveal the ACC changes in resting-state activity and connectivity in the elderly with StD, suggesting that altered ALFF/FC of the adACC is an important feature of StD.
前扣带皮层（ACC）被认为是抑郁症发病机制中的关键结构。本研究旨在调查社区样本人群中阈下抑郁（StD）老年人的 ACC 的静息状态区域活动和功能连接。我们使用静息态功能磁共振成像从 19 名 StD 老年患者和 18 名正常对照中获取数据。我们使用局部低频波动幅度（ALFF）分析和基于相关的功能连接（FC）方法来探索 StD 中 ACC 的局部活动和远程连接的变化。与对照组相比，StD 组在背侧 ACC（adACC）的前部分显示出更高的 ALFF。adACC 还显示与背外侧前额叶皮层和补充运动区的 FC 增加，与几个皮质下区域的 FC 减少。adACC 的 FC 水平与自我报告的抑郁症状呈趋势相关。本研究首次揭示了 StD 老年人静息状态下 ACC 活动和连接的变化，表明 adACC 的改变的 ALFF/FC 是 StD 的一个重要特征。
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