Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, China.
Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, China; Respiratory Medicine, The Central Hospital of Xiangtan City, Hunan, China.
Int J Infect Dis. 2014 Jun;23:1-3. doi: 10.1016/j.ijid.2013.12.019. Epub 2014 Mar 19.
Penicillium marneffei is a thermally dimorphic pathogenic fungus that causes systemic infection similar to disseminated cryptococcosis. P. marneffei is endemic in Southeast Asia, usually infecting HIV-infected individuals; infection of HIV-negative individuals is extremely rare. Here, we describe a disseminated P. marneffei infection within an osteolytic lesion in an HIV-negative patient. A 40-year-old Chinese woman presented with intermittent fever, generalized lymphadenopathy, and a skin rash. Following a sternum biopsy, the patient was diagnosed with P. marneffei infection. An emission computed tomography bone scan revealed the presence of increased radioactivity in the left clavicle and sternum, indicative of an osteolytic lesion. In addition to reporting this very rare case, we also present a brief review of the literature, highlighting the differences in clinical manifestations between HIV-positive and HIV-negative patients infected with P. marneffei as it applies to our case.
马尔尼菲青霉是一种热双相致病真菌，可引起类似于播散性隐球菌病的全身感染。马尔尼菲青霉在东南亚流行，通常感染 HIV 感染者；HIV 阴性者的感染极为罕见。在这里，我们描述了一例 HIV 阴性患者溶骨性病变内播散性马尔尼菲青霉感染。一名 40 岁的中国女性出现间歇性发热、全身淋巴结肿大和皮疹。胸骨活检后，该患者被诊断为马尔尼菲青霉感染。发射型计算机断层扫描骨扫描显示左侧锁骨和胸骨放射性活性增加，提示溶骨性病变。除了报告这一非常罕见的病例外，我们还简要回顾了文献，重点介绍了 HIV 阳性和 HIV 阴性患者感染马尔尼菲青霉的临床表现差异，这与我们的病例有关。
