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马尔尼菲青霉和沙门氏菌致 HIV 感染者合并骨关节感染 1 例报告

Osteoarticular infection caused by Talaromyces Marneffei and Salmonella in a person living with HIV: a case report.

机构信息

Department II of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, China.

出版信息

BMC Infect Dis. 2023 Aug 28;23(1):560. doi: 10.1186/s12879-023-08554-9.

DOI:10.1186/s12879-023-08554-9
PMID:37641024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10463968/
Abstract

INTRODUCTION

Talaromycosis is a common invasive fungal disease in patients with HIV. However, its association with bone destruction is unusual in AIDS patients with talaromycosis.

CASE PRESENTATION

This report covers the case of a 38-year-old male AIDS patient coinfected with Talaromyces marneffei and Salmonella. The case, which involved bone destruction, was identified via metagenomic next-generation sequencing (mNGS). Following treatment with a combination of amphotericin B and piperacillin-tazobactam, the patient's elbow motion noticeably improved. Imaging findings revealed that the progression of bony destruction had halted.

CONCLUSION

Bone damage due to Talaromyces marneffei infection is infrequent in HIV-positive patients. Therefore, healthcare professionals must be vigilant for potential bone lesions associated with this type of infection. Prompt diagnosis and antimicrobial treatment are crucial.

摘要

简介

马尔尼菲篮状菌病是 HIV 患者常见的侵袭性真菌感染。然而，在感染马尔尼菲篮状菌的艾滋病患者中，其与骨破坏相关并不常见。

病例介绍

本报告涵盖了一例 38 岁男性艾滋病患者，同时感染了马尔尼菲篮状菌和沙门氏菌。通过宏基因组下一代测序（mNGS）发现了该例涉及骨破坏的病例。经过两性霉素 B 和哌拉西林他唑巴坦联合治疗后，患者的肘部运动明显改善。影像学发现骨破坏的进展已停止。

结论

在 HIV 阳性患者中，马尔尼菲篮状菌感染引起的骨损伤并不常见。因此，医护人员必须警惕与这种类型的感染相关的潜在骨病变。及时诊断和抗菌治疗至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0b/10463968/b31b99ed1d2c/12879_2023_8554_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0b/10463968/42624382557e/12879_2023_8554_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0b/10463968/15ff4ab94c19/12879_2023_8554_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0b/10463968/b31b99ed1d2c/12879_2023_8554_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0b/10463968/42624382557e/12879_2023_8554_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0b/10463968/a14c376c4013/12879_2023_8554_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0b/10463968/5f63876f9071/12879_2023_8554_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0b/10463968/15ff4ab94c19/12879_2023_8554_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d0b/10463968/b31b99ed1d2c/12879_2023_8554_Fig5_HTML.jpg

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本文引用的文献

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Front Cell Infect Microbiol. 2022 Sep 8;12:987692. doi: 10.3389/fcimb.2022.987692. eCollection 2022.
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Metagenomic next-generation sequencing for the early diagnosis of talaromycosis in HIV-uninfected patients: five cases report.宏基因组下一代测序在 HIV 阴性患者中早期诊断足放线病菌病：五例报告。
BMC Infect Dis. 2021 Aug 23;21(1):865. doi: 10.1186/s12879-021-06551-4.
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