Pedersen M, Nielsen P B, Permin H, Norn S, Mojon M, Skov P S, Faber V
Laboratory of Immunology, University Clinic for Infectious Diseases M, Rigshospitalet, Copenhagen, Denmark.
APMIS. 1989 Feb;97(2):120-4.
Type I allergy directed against Pneumocystis carinii (PC) has been investigated in 14 patients with AIDS. The Pneumocystis carinii pneumonia often shows a rapid and severe course, and type I allergy against the parasite might be a pathogenic co-factor in the interstitial lung inflammation. In twelve of the AIDS patients the clinical symptoms and course of illness indicated a PC pneumonia. The basophil histamine release test was used as a sensitive test to detect type I allergy against PC. Eight of the patients showed significant histamine release when stimulated with PC. In contrast, only two patients in the group of 12 HIV antibody-positive homosexual men and none in the control group of 13 heterosexual men released histamine. The histamine release was mediated by an immunological reaction, since the release was abolished and regained by removal from and refixation to the cell surface of the cell-bound immunoglobulins before the antigen challenge. The results suggest an involvement of type I allergy as a pathogenic co-factor in Pneumocystis carinii pneumonia.
对14例艾滋病患者进行了针对卡氏肺孢子虫（PC）的I型过敏反应研究。卡氏肺孢子虫肺炎通常呈快速且严重的病程，针对该寄生虫的I型过敏反应可能是间质性肺炎的致病辅助因素。在12例艾滋病患者中，临床症状和病程提示为PC肺炎。采用嗜碱性粒细胞组胺释放试验作为检测针对PC的I型过敏反应的敏感试验。8例患者在受到PC刺激时出现显著的组胺释放。相比之下，在12例HIV抗体阳性的同性恋男性组中只有2例患者释放组胺，而在13例异性恋男性对照组中无一人释放组胺。组胺释放是由免疫反应介导的，因为在抗原攻击前，通过从细胞表面去除并重新固定细胞结合免疫球蛋白，释放被消除并恢复。结果表明I型过敏反应作为致病辅助因素参与了卡氏肺孢子虫肺炎。
