van den Dries Koen, Bolomini-Vittori Matteo, Cambi Alessandra
Department of Tumor Immunology; Radboud Institute for Molecular Life Sciences; Radboud University Medical Center; Nijmegen, The Netherlands.
Department of Tumor Immunology; Radboud Institute for Molecular Life Sciences; Radboud University Medical Center; Nijmegen, The Netherlands; Department of Nanobiophysics; MESA+ Institute for Nanotechnology and MIRA Institute for Biomedical Technology and Technical Medicine; University of Twente; Enschede, The Netherlands.
Cell Adh Migr. 2014;8(3):268-72. doi: 10.4161/cam.28182.
Podosomes are small, circular adhesions formed by cells such as osteoclasts, macrophages, dendritic cells, and endothelial cells. They comprise a protrusive actin core module and an adhesive ring module composed of integrins and cytoskeletal adaptor proteins such as vinculin and talin. Furthermore, podosomes are associated with an actin network and often organize into large clusters. Recent results from our laboratory and others have shed new light on podosome structure and dynamics, suggesting a revision of the classical "core-ring" model. Also, these studies demonstrate that the adhesive and protrusive module are functionally linked by the actin network likely facilitating mechanotransduction as well as providing feedback between these two modules. In this commentary, we briefly summarize these recent advances with respect to the knowledge on podosome structure and discuss force distribution mechanisms within podosomes and their emerging role in mechanotransduction.
足体是由破骨细胞、巨噬细胞、树突状细胞和内皮细胞等细胞形成的小的圆形黏附结构。它们由一个突出的肌动蛋白核心模块和一个由整合素以及诸如纽蛋白和踝蛋白等细胞骨架衔接蛋白组成的黏附环模块构成。此外，足体与肌动蛋白网络相关联，并且常常组织成大的簇。我们实验室和其他实验室最近的研究结果为足体的结构和动力学带来了新的认识，这表明需要对经典的“核心-环”模型进行修正。而且，这些研究表明，黏附模块和突出模块通过肌动蛋白网络在功能上相联系，这可能有助于机械转导，并在这两个模块之间提供反馈。在这篇评论中，我们简要总结了关于足体结构的这些最新进展，并讨论了足体内的力分布机制及其在机械转导中日益凸显的作用。
