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Cancer statistics, 2013.癌症统计数据，2013 年。
CA Cancer J Clin. 2013 Jan;63(1):11-30. doi: 10.3322/caac.21166. Epub 2013 Jan 17.
2
Ovarian cancer and smoking: individual participant meta-analysis including 28,114 women with ovarian cancer from 51 epidemiological studies.卵巢癌与吸烟：包含 51 项流行病学研究中 28114 名卵巢癌患者的个体参与者荟萃分析。
Lancet Oncol. 2012 Sep;13(9):946-56. doi: 10.1016/S1470-2045(12)70322-4. Epub 2012 Aug 3.
3
Ovarian cancer: etiology, risk factors, and epidemiology.卵巢癌：病因、风险因素及流行病学
Clin Obstet Gynecol. 2012 Mar;55(1):3-23. doi: 10.1097/GRF.0b013e31824b4611.
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Global cancer statistics.全球癌症统计数据。
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4.
5
No activating mutations of FSH receptor in four children with ovarian juvenile granulosa cell tumors and the association of these tumors with central precocious puberty.4例卵巢幼年型颗粒细胞瘤患儿中未发现促卵泡激素受体激活突变及其与中枢性性早熟的关系
J Pediatr Adolesc Gynecol. 2009 Jun;22(3):173-9. doi: 10.1016/j.jpag.2008.10.003.
6
Androgen, progesterone, and FSH receptor polymorphisms in ovarian cancer risk and outcome.雄激素、孕激素和促卵泡激素受体基因多态性与卵巢癌风险及预后的关系
Endocr Relat Cancer. 2009 Sep;16(3):1005-16. doi: 10.1677/ERC-08-0135. Epub 2009 May 20.
7
Analysis of single nucleotide polymorphisms of FSH receptor gene suggests association with testicular cancer susceptibility.促卵泡激素受体基因单核苷酸多态性分析提示其与睾丸癌易感性相关。
Endocr Relat Cancer. 2008 Jun;15(2):429-37. doi: 10.1677/ERC-07-0257. Epub 2008 Apr 22.
8
[Follicle-stimulating hormone receptor polymorphism and ovarian function].[促卵泡激素受体多态性与卵巢功能]
Gynecol Obstet Fertil. 2007 Feb;35(2):135-41. doi: 10.1016/j.gyobfe.2006.10.035. Epub 2007 Feb 14.
9
Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility.促卵泡激素受体的单核苷酸多态性与卵巢癌易感性相关。
Carcinogenesis. 2006 Jul;27(7):1502-6. doi: 10.1093/carcin/bgl014. Epub 2006 Mar 30.
10
A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle.人类促卵泡激素受体第10外显子中的一种常见单核苷酸多态性是月经周期长度和激素动态变化的主要决定因素。
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促卵泡激素受体基因Asn680Ser多态性与卵巢癌风险：一项荟萃分析。

The Asn680Ser polymorphism of the follicle stimulating hormone receptor gene and ovarian cancer risk: a meta-analysis.

作者信息

Qin Xue, Ma Liping, Yang Shi, Zhao Jianyang, Chen Siyuan, Xie Yantong, Wang Jian, Li Taijie, He Yu, Peng Qiliu, Deng Yan, Li Shan, Qin Aiping

出版信息

J Assist Reprod Genet. 2014 Jun;31(6):683-8. doi: 10.1007/s10815-014-0218-z.

DOI:10.1007/s10815-014-0218-z
PMID:24658926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4048372/
Abstract

PURPOSE

The purpose of this study was to conduct a meta-analysis to assess the association between FSHR Asn680Ser polymorphism and ovarian cancer susceptibility.

METHODS

A literature search was conducted in PubMed, Embase and the China National Knowledge Infrastructure (CNKI) for all relevant studies published up to September 2013. The pooled odds ratios (ORs) with the corresponding 95 % confidence intervals (95 % CIs) were calculated to evaluate the association.

RESULTS

Four case-control studies including 474 ovarian cancer cases and 659 controls met the inclusion criteria. The pooled analyses showed that FSHR Asn680Ser polymorphism was associated with the risk of ovarian cancer (Ser vs Asn: OR=1.295, 95 % CI 1.057-1.498, P=0.01; Ser/Ser + Asn/Ser vs Asn/Asn: OR=1.611, 95 % CI 1.027-2.528, P=0.038). Subgroup analyses by ethnicity (Caucasian and Asian) further revealed significant associations among Asians (Ser vs Asn: OR=1.386, 95 % CI 1.066-1.802, P=0.015; Ser/Ser + Asn/Ser vs Asn/Asn: OR=1.893, 95 % CI 1.329-2.689, P=0.000) but not Caucasians. There was no obvious risk of publication bias.

CONCLUSIONS

The meta-analysis suggests that FSHR Asn680Ser polymorphism may be a risk factor for ovarian cancer in Asians. Due to the limited quantity of the included studies, further studies are needed to validate the above conclusions.

摘要

目的

本研究旨在进行一项荟萃分析，以评估促卵泡激素受体（FSHR）Asn680Ser多态性与卵巢癌易感性之间的关联。

方法

在PubMed、Embase和中国知网（CNKI）中检索截至2013年9月发表的所有相关研究。计算合并优势比（OR）及相应的95%置信区间（95%CI）以评估关联性。

结果

四项病例对照研究（包括474例卵巢癌病例和659例对照）符合纳入标准。汇总分析表明，FSHR Asn680Ser多态性与卵巢癌风险相关（Ser与Asn相比：OR = 1.295，95%CI 1.057 - 1.498，P = 0.01；Ser/Ser + Asn/Ser与Asn/Asn相比：OR = 1.611，95%CI 1.027 - 2.528，P = 0.038）。按种族（白种人和亚洲人）进行的亚组分析进一步显示，亚洲人之间存在显著关联（Ser与Asn相比：OR = 1.386，95%CI 1.066 - 1.802，P = 0.015；Ser/Ser + Asn/Ser与Asn/Asn相比：OR = 1.893，95%CI 1.329 - 2.689，P = 0.000），而白种人则不然。没有明显的发表偏倚风险。

结论

荟萃分析表明，FSHR Asn680Ser多态性可能是亚洲人患卵巢癌的一个风险因素。由于纳入研究数量有限，需要进一步研究来验证上述结论。