Chen Dao-Jun, Ding Rui, Cao Ji-Yu, Zhai Jin-Xia, Zhang Jia-Xiang, Ye Dong-Qing
Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China; The Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
Eur J Obstet Gynecol Reprod Biol. 2014 Nov;182:27-32. doi: 10.1016/j.ejogrb.2014.08.014. Epub 2014 Aug 15.
The aim of this study was to explore the association between follicle stimulating hormone receptor (FSHR) Thr307Ala and Asn680Ser polymorphisms and susceptibility to polycystic ovary syndrome (PCOS). A comprehensive literature search for relevant studies was conducted on Google Scholar, PubMed, the Chinese National Knowledge Infrastructure (CNKI) and the Chinese Biomedical Literature Database (CBM). This meta-analysis was performed using the STATA 11.0 software and the pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Ten case-control studies were included in this meta-analysis. However, meta-analysis results showed no association between both FSHR Thr307Ala polymorphism and Asn680Ser polymorphism and susceptibility to PCOS. Stratified analysis of ethnicities also showed no association. In conclusion, the present study suggested that the FSHR polymorphisms were not associated with an increased risk of PCOS and larger-scale studies of populations are needed to explore the roles played by FSHR polymorphisms during the pathogenesis of PCOS.
本研究旨在探讨促卵泡激素受体（FSHR）Thr307Ala和Asn680Ser多态性与多囊卵巢综合征（PCOS）易感性之间的关联。通过在谷歌学术、PubMed、中国知网（CNKI）和中国生物医学文献数据库（CBM）上全面检索相关研究。使用STATA 11.0软件进行本荟萃分析，并计算合并比值比（OR）及95%置信区间（CI）。本荟萃分析纳入了10项病例对照研究。然而，荟萃分析结果显示FSHR Thr307Ala多态性和Asn680Ser多态性与PCOS易感性之间均无关联。按种族进行的分层分析也未显示出关联。总之，本研究表明FSHR多态性与PCOS风险增加无关，需要开展更大规模的人群研究以探索FSHR多态性在PCOS发病机制中所起的作用。
