Qiu Lei, Liu Jing, Hei Qi-ming
Department of Health Management, School of Management, Hainan Medical University, Haikou 570100, China.
Department of Labor and Social Security, School of Management, Hainan Medical University, Haikou 570100, China.
Chin Med Sci J. 2015 Mar;30(1):44-50. doi: 10.1016/s1001-9294(15)30008-0.
To investigate the association between two polymorphisms of follicle stimulating hormone receptor (FSHR) gene and polycystic ovary syndrome (PCOS) susceptibility.
Case-control studies on relationship of Thr307Ala and Asn680Ser polymorphisms in FSHR gene and PCOS susceptibility were searched from PubMed, ISI web of knowledge, EBSCO, and China National Knowledge Infrastructure (CNKI) databases up to March 21, 2013. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed- or random-effect model based on heterogeneity test in 5 genotype models analyses.
A total of 11 studies were included in the Meta-analysis. The random-effect analysis showed Asn680Ser was significantly associated with the reduced susceptibility to PCOS with dominant model (Asn/Asn+Asn/Ser vs. Ser/Ser, OR=0.83, 95% CI: 0.69-1.00), recessive model (Asn/Asn vs. Asn/Ser+ Ser/Ser, OR=0.84, 95% CI: 0.72-0.98), homozygote comparison (Asn/Asn vs. Ser/Ser, OR=0.79, 95% CI: 0.63-0.98), and the allele contrast (Asn vs. Ser, OR=0.87, 95% CI: 0.79-0.97) respectively(P=0.02, I(2)=56.0%), being protective factors for PCOS. However, no significant associations were found between Thr307Ala and PCOS.
There might be a significant association between Asn680Ser polymorphism and PCOS.
探讨促卵泡激素受体（FSHR）基因的两个多态性与多囊卵巢综合征（PCOS）易感性之间的关联。
检索截至2013年3月21日的PubMed、ISI知识网络、EBSCO和中国知网（CNKI）数据库，查找关于FSHR基因中Thr307Ala和Asn680Ser多态性与PCOS易感性关系的病例对照研究。在5种基因型模型分析中，根据异质性检验，采用固定效应或随机效应模型计算合并比值比（OR）和95%置信区间（CI）。
Meta分析共纳入11项研究。随机效应分析显示，在显性模型（Asn/Asn+Asn/Ser vs. Ser/Ser，OR=0.83，95%CI：0.69-1.00）、隐性模型（Asn/Asn vs. Asn/Ser+Ser/Ser，OR=0.84，95%CI：0.72-0.98）、纯合子比较（Asn/Asn vs. Ser/Ser，OR=0.79，95%CI：0.63-0.98）和等位基因对比（Asn vs. Ser，OR=0.87，95%CI：0.79-0.97）中，Asn680Ser分别与PCOS易感性降低显著相关（P=0.02，I²=56.0%），是PCOS的保护因素。然而，未发现Thr307Ala与PCOS之间存在显著关联。
Asn680Ser多态性与PCOS之间可能存在显著关联。
