From the Department of Systems Neuroscience, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Neurology. 2014 Apr 22;82(16):1416-24. doi: 10.1212/WNL.0000000000000337. Epub 2014 Mar 21.
The aim of the study was to determine whether various transient sensory and neuropsychological symptoms (SNS) were associated with migraine using a custom questionnaire.
In this hypothesis-generating case-control study, the frequencies of transient SNS in 219 patients with migraine (149 without aura and 70 with aura) were compared with 161 age- and sex-matched healthy controls using a custom questionnaire. Patients from a tertiary academic headache center in Hamburg were contacted by regular mail. Healthy controls without a history of migraine were recruited by means of a screening questionnaire and consecutively approached by e-mail.
The presence of both migraine and aura was associated with significantly higher frequencies of autokinesis, metamorphopsia, dyschromatopsia, cinematographic vision, illusionary visual spread, and synesthesia (for all comparisons: corrected p < 0.05). Double vision, inverted 2- and 3-dimensional vision, and altered perception of body weight and size were found more often in patients with migraine without aura than in those with aura. In contrast, aura was associated with the occurrence of visual splitting and corona phenomenon (for all comparisons: corrected p < 0.05). No relevant association with migraine was found for micropsia and macropsia, teleopsia and pelopsia, inverted vision, out-of-body experience, Doppelgänger phenomenon, complex visual hallucinations, and altered perception of body position in space.
The observed SNS seem to belong to a physiologic spectrum of multisensory phenomena. Some of these phenomena were significantly accentuated in patients with migraine and may therefore be termed migraine trait symptoms. However, these results will have to be confirmed in a prospective study with face-to-face interviews.
本研究旨在通过定制问卷，确定各种短暂感觉和神经心理症状（SNS）是否与偏头痛有关。
在这项假设生成的病例对照研究中，使用定制问卷比较了 219 例偏头痛患者（149 例无先兆和 70 例有先兆）与 161 例年龄和性别匹配的健康对照者的短暂 SNS 频率。通过普通邮件联系汉堡一家三级学术头痛中心的患者。通过筛选问卷招募无偏头痛病史的健康对照者，并通过电子邮件连续接触。
偏头痛和先兆的存在与更高频率的自动运动、变形、色觉障碍、电影视觉、幻觉视觉扩散和联觉（所有比较：校正后 p <0.05）显著相关。复视、2-和 3 维颠倒视觉以及对体重和大小的感知改变在无先兆偏头痛患者中比有先兆偏头痛患者中更常见。相比之下，先兆与视觉分裂和冠状现象的发生相关（所有比较：校正后 p <0.05）。微视和巨视、远距视和近距视、颠倒视觉、身体出窍体验、 Doppelgänger 现象、复杂视觉幻觉以及对身体在空间中的位置的感知改变与偏头痛无明显相关性。
观察到的 SNS 似乎属于多感官现象的生理谱。其中一些现象在偏头痛患者中明显加重，因此可称为偏头痛特征症状。然而，这些结果需要在面对面访谈的前瞻性研究中得到证实。
